Memory Training and Neural Plasticity

Mild Cognitive Impairment Clinical Trial

— WMTrain  

Official title:

Working Memory Training and Neural Plasticity in Mild Cognitive Impairment

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05380739
• Other study ID #: HUM00199574
• Status: Recruiting
• Phase: N/A
• Start date: April 7, 2022
• Est. completion date: September 1, 2024

Study information

• Verified date: November 2023
• Source: University of Michigan
• Contact: Alexandru Iordan, Ph.D
• Phone: 734-764-2909
• Email: adiordan[@]umich.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will evaluate the efficacy of working memory training in older adults with amnestic mild cognitive impairment (MCI).

Description:

Working memory (WM) is the ability to hold information actively in mind and is fundamental for higher-order cognition. This pilot study aims to (1) evaluate the efficacy of WM training in older adults with MCI and (2) understand if and how it works. The study will use behavioral and brain imaging assessments to see whether WM training changes how participants learn and remember information. Functional magnetic resonance imaging (fMRI) and functional near infrared spectroscopy (fNIRS) methods will be used. The study will also use cognitive tests and questionnaires to determine whether participants' cognitive abilities change with training. The study will enroll participants with a diagnosis of MCI as well as cognitively intact older adults (healthy controls, HC).

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: September 1, 2024
• Est. primary completion date: September 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

• MCI Diagnosis
• Right-handedness
• MRI-eligibility for MRI participants

Exclusion Criteria:

• History of other contributing neurological or medical conditions known to affect cognitive functioning
• Significant mental illness
• Sensory impairments that limit ability to participate
• History of alcohol or drug abuse/dependence

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Mild Cognitive Impairment

Intervention

Behavioral:
• Working Memory Training
A 10-session working memory (WM) training program

Locations

Country	Name	City	State
United States	University of Michigan	Ann Arbor	Michigan

Sponsors (1)

Lead Sponsor	Collaborator
University of Michigan

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Gains in WM training task performance	Analyses of WM performance for each training session indexed as the mean set-size achieved during each training session for each participant	2 weeks
Primary	Changes in brain activation within the WM network	Univariate analyses via fMRI and fNIRS, respectively, using units of brain activation (i.e., contrast estimates)	2 weeks
Secondary	Changes in criterion (fMRI) WM task performance	Analyses of WM performance indexed as percent accuracy	2 weeks
Secondary	Changes in functional connectivity within and between canonical brain networks	Graph theory analysis via fMRI and fNIRS, respectively, using measures of connectivity strength (i.e., correlation coefficients)	2 weeks