Mild Cognitive Impairment Clinical Trial
Official title:
The Effects of Tai Chi on Cognition and Instrumental Activities of Daily Living, and Health Related Quality of Life in Older People With Mild Cognitive Impairment .
Verified date | January 2018 |
Source | Chinese University of Hong Kong |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The prevalence of older people with cognitive decline is increasing since the aging
population is growing substantially worldwide. Cognitive impairment places older adults at
high risk for functional disability. Previous researches have provided strong evidence on the
beneficial effects of physical exercise on maintaining cognitive functions in older adults.
Tai Chi is considered as a low to moderate intensity exercise, which is performed in a slow
and rhythmic movement. It is a popular and safe exercise suitable for older people who have
weaker muscle strength. The aim of this study was to determine the effects of Tai Chi on
cognition and instrumental activities of daily living (I-ADLs), and health-related quality of
life (HRQOL) in older Chinese adults with mild cognitive impairment (MCI).
The research hypothesis of the study stated: There is significant improvement in the general
cognitive performance, functional capabilities of instrumental ADLs,the physical component
and mental component of HRQOL between the group of community-dwelling older people with MCI
who have participated and the control group who have not participated in the Tai Chi program.
Status | Completed |
Enrollment | 160 |
Est. completion date | September 1, 2016 |
Est. primary completion date | September 1, 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 60 Years and older |
Eligibility |
Inclusion Criteria: - Chinese people aged 60 years or above; - Obtained the CMMSE screening score ranging from 19 to 28, which was corrected based on educational level (= 18 for illiterate respondents and = 22 for those having received more than two years of education); - Have ability to perform self-care functions on their own; - No confirmed diagnosis of dementia, depression or other psychiatric illnesses; - Not engaged in any structured physical exercise program or Tai Chi practice in the preceding year. Exclusion Criteria: - Had a medical history of chronic alcoholism or brain trauma occurred in previous years; - Regular users of medications that could affect cognition; - Contraindicated light to moderate physical exercise. |
Country | Name | City | State |
---|---|---|---|
Hong Kong | The Chinese University of Hong Kong | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
Chinese University of Hong Kong |
Hong Kong,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change from baseline C-MMSE score at four months | The Chinese version of Mini-Mental State Examination (C-MMSE) is a global cognitive assessment tool.The first part of the CMMSE assesses respondent's abilities on orientation, memory and attention and the second part tests respondent's ability to name objects, understanding on verbal and written commands; higher score indicates for better cognitive performance. | he outcome assessment was conducted at baseline, and at 4 month (at the end of study) | |
Secondary | Change from baseline IADL-CV score at four months | The Hong Kong Chinese version of Lawton Instrumental Activities of Daily Living (IADL-CV) is used to assess participants' performance level of instrumental activities of daily living. Nine domains of instrumental ADLs are assessed, including ability to use telephone, shopping, food preparation, house-keeping, laundry, use of transportation, financial management, handling medication and handyman work. Higher score for each domain represents better functional performance of the older people. | The outcome assessment was conducted at baseline, and at 4 month (at the end of study) | |
Secondary | Change from baseline SF-12 score at four months | The Chinese version of the Short Form-12 Health Survey- Standard 1 (SF-12) is a brief version of the MOS 36-Item Short Form Health Survey (SF-36), incorporating 12 items rated on a Likert scale. It is employed to assess the perceived health status of the participants. It consists of 2 main components, the physical health and the mental health components.The physical health component (PCS) weighs the physical functioning, role-physical, bodily pain, and general health status of an individual. The mental health component (MCS) assesses on vitality, social functioning, role-emotional and general mental health status. Higher scores show better health conditions. | The outcome assessment was conducted at baseline, and at 4 month (at the end of study) |
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