Mild Cognitive Impairment Clinical Trial
Official title:
A Randomized Control Trial on Computerized Cognitive Training for Individuals With Mild Cognitive Impairment
The objective of the study is to evaluate whether memory training combined with executive training could lead to improved cognitive and noncognitive performance in patients with MCI. Furthermore, we will explore the neural correlates underlying the changed performances.
Introduction:
Mild cognitive impairment (MCI) is a clinical condition characterized of a reduction in
memory and/or other cognitive processes that are insufficiently severe to be diagnosed as
dementia, but are more pronounced than the cognitive decline associated with normal aging.
The prevalence of MCI ranges from 3% to 19% in adults older than 65 years; some of these
individuals seem to remain stable or return to normal over time, but more than half progress
to dementia within 5 years. Thus, MCI represents a critical window of opportunity for
intervening and altering the trajectory of both cognitive decline and loss of functional
independence in older adults. Cognitive function apart from memory such as executive function
is also impaired in patients with MCI. However, no study has yet placed sufficient emphasis
on the training of executive function.
Objectives:
The objective of the study is to evaluate whether memory training combined with executive
training could lead to improved cognitive and noncognitive performance in patients with MCI.
Furthermore, we will explore the neural correlates underlying the changed performances.
Patients and Methods:
The proposed study is a single blinded, randomized and controlled trial that will include 120
elderly patients with MCI from the memory clinic. The groups will be randomized to either
intervention or waiting-list group. The intervention is computerized combined memory and
executive function training performed for 60 minutes x 4 times/week over 26 weeks. A
neuropsychological assessment will be administered at baseline and week 4, 12 and 26 after
the intervention. The structural and functional MRI, EEG and NIRS will be performed at
baseline and week 26 after intervention for a sub-study on the effect of cognitive training
on brain structure and function.
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