Mild Cognitive Impairment Clinical Trial
Official title:
Effect of a Modified Ketogenic-Mediterranean Diet on Alzheimer's Disease
The purpose of the BEAM study is to compare the effects of a low-carbohydrate diet and a lowfat diet for adults with mild memory loss and adults with pre-diabetes. The data collected will help determine changes in cognitive function, brain structure and function, and levels of certain proteins and hormones in body fluids.
Participants will be enrolled into 1 of 3 study groups. Group 1 will include healthy
volunteers with no apparent memory problems, memory complaints or family history of
Alzheimer's disease or dementia. This group will complete cognitive assessments, blood and
stool sample collection, neuroimaging, and lumbar puncture at week 0 only. Group 1 will NOT
take part in the diet study.
Group 2 will have pre-diabetes, but no apparent memory problems that can be observed during
cognitive testing. Group 2 will complete an 18-week diet study, with follow-up assessment 6
weeks after final diet completion. Throughout the study the following will also be completed;
cognitive assessments, blood and stool sample collection, neuroimaging, and lumbar puncture.
Group 3 will have mild memory problems that are observed during cognitive testing. Group 3
will complete an 18-week diet study, with follow-up assessment 6 weeks after diet final
completion. Throughout the study the following will also be completed; cognitive assessments,
blood and stool sample collection, neuroimaging, and lumbar puncture.
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