Mild Cognitive Impairment Clinical Trial
Official title:
Intervention to Reduce Sitting Time in Mild Cognitive Impairment
The purpose of this study is to determine whether the researchers can help people change the amount of time they spend in sitting activities and whether this change might improve health outcomes.
Specific Aim 1: Determine feasibility of a 12-week home and telephone based intervention in
older adults with mild cognitive impairment targeting both the impaired individual and their
study partner to help initiate and maintain behavior change. We will recruit KUADC registry
participants with MCI and their caregivers (as study partners). Behavioral interventions are
more effective when there is built in social support. We will evaluate feasibility in terms
of successful recruitment and retention of participants, 10% or less of technological
failures, rate of participant concerns addressed by phone and at home visits, acceptability
of the intervention to participants (measured by questionnaires during home visits).
Specific Aim 2: Determine whether a 12-week home and telephone based intervention results in
reduced total sitting time and shorter bouts of sitting in older adults with MCI and their
caregivers. Electronic postural monitors will record sitting time for a duration of one week
at three time points (pre-intervention, mid-intervention, and post-intervention). The
intervention includes 1) feedback from baseline monitoring, 2) educational and goal setting
session with the participants and research staff, 3) wrist worn monitors that alert wearers
to sitting times >30 minutes, 4) home and telephone visits to address physical,
psychological, and home environment barriers to behavior change. Changes in sitting time and
breaks from sitting will be compared between baseline, mid-intervention, and
post-intervention measurement occasions.
Specific Aim 3: Determine whether sedentary behavior intervention results in improved insulin
sensitivity and glycemic control. To evaluate whether reduced sitting results in meaningful
metabolic changes, we will measure postprandial insulin and glucose, and body composition,
and evaluate changes from pre- to post- intervention adjusting for relevant covariates.
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