Mild Cognitive Impairment Clinical Trial
Official title:
Art Therapy and Music Reminiscence Activity in the Prevention of Cognitive Decline
The objective of this study is to determine the impact of Art Therapy and Music Reminiscence
Activity on cognition in community living elderly with Mild Cognitive Impairment (DSM V: Mild
Neurocognitive Disorder) using a randomized control design.
Specifically, the structural cerebral changes that occur with the two interventions and the
extent to which the therapies may reverse cognitive impairment and/or prevent further
cognitive decline, will be determined.
The hypothesis is that participants in both active intervention arms will perform better on
neuropsychological tests of cognition and will show positive changes on functional imaging
studies compared to controls who will not receive any intervention. Participants in the
interventions will also have positive changes in blood biomarkers, enhanced psychological
well-being and reductions in anxiety and depressive symptoms compared to the control group.
No a priori hypotheses were developed as to whether Art Therapy or Music Reminiscence
Activity is more effective as the comparison is exploratory.
Participants: 90 community-living elderly, with mild cognitive impairment.
Interventions: Participants will be randomized into 3 arms: Art Therapy, Music Reminiscence
Activity or a Control arm. Sessions will be conducted weekly for 3 months and fortnightly for
6 months. Each intervention session will last for 40 minutes. The Control group will not
receive any intervention and continue their life as usual.
Assessments: Demographic data will be collected at baseline. Neuropsychological tests of
cognitive functioning will be done at baseline, 3 months and 9 months. Anxiety and depressive
symptoms will be assessed at the 3 time-points. Blood sampling will occur at all time points
(except control group, only at baseline and 9 months). Participants will also undergo a
task-free brain fMRI scan at baseline and at 3 months.
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