Therapeutic Efficacy of Categorical Language Fluency Smartphone Game Application

Mild Cognitive Impairment Clinical Trial

Official title:

A Study of Therapeutic Efficacy of Categorical Language Fluency Smartphone Game Application in Mild Cognitive Impairment and Mild Alzheimer's Dementia (Baseline Study)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02848404
• Other study ID #: 2010-0028631
• Status: Completed
• Phase: N/A
• Start date: June 2016
• Est. completion date: February 2017

Study information

• Verified date: March 2020
• Source: Seoul National University Bundang Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to examine therapeutic efficacy of categorical language fluency smartphone game application in mild cognitive impairment and mild Alzheimer's dementia.

Description:

The Categorical Language Fluency Smartphone Game Application was developed based on the semantic distance training, which was effective in improving categorical language fluency of mild cognitive impairment and mild Alzheimer's dementia. 10 patients with mild cognitive impairment and another 10 patients with mild Alzheimer's dementia were recruited to examine therapeutic efficacy of the application.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: February 2017
• Est. primary completion date: December 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 55 Years and older

Eligibility

Inclusion Criteria:

• Aged above 55

• Confirmed literacy

• Diagnosed to mild cognitive impairment by International Working Group on Mild Cognitive Impairment and Clinical Dementia Rating(CDR) of 0 or 0.5.

• Diagnosed to possible or probable Alzheimer's dementia by NINCDS-ADRDA and Clinical Dementia Rating(CDR) of 1 or below.

Exclusion Criteria:

• Evidence of delirium, confusion

• Any neurological conditions causing cognitive decline such as Parkinson's disease, brain hemorrhage, brain tumor, normal pressure hydrocephalus

• Evidence of severe cerebrovascular pathology

• History of loss-of-consciousness over 1 hour due to head trauma or repetitive head trauma of mild severity

• History of substance abuse or dependence such as alcohol

• Presence of depressive symptoms that could influence cognitive function

• Presence of medical comorbidities that could result in cognitive decline

Related Conditions & MeSH terms

• Alzheimer Disease
• Alzheimer's Disease
• Cognitive Dysfunction
• Mild Cognitive Impairment

Intervention

Device:
• Categorical Language Fluency Smartphone Application
4 weeks' training

Locations

Country	Name	City	State
n/a

Sponsors (3)

Lead Sponsor	Collaborator
Seoul National University Bundang Hospital	Ministry of Science, ICT and Future Planning, Seoul National University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Application usage log	Log to assess compliance of participant(by describing frequency and duration of training by using application)	4-weeks treatment
Secondary	Subjective Memory Complaint Questionnaire	to evaluate efficacy of application	after 4-weeks treatment
Secondary	Geriatric Depression Scale	to evaluate efficacy of application	after 4-weeks treatment
Secondary	Korean version of MMSE for dementia screening	to evaluate efficacy of application	after 4-weeks treatment