Mild Cognitive Impairment Clinical Trial
Official title:
Auditory Stimulation of Slow Wave Sleep and Memory in Mild Cognitive Impairment and Older Adults
This study will evaluate the ability of sounds played during slow wave sleep using a phase locked loop algorithm to enhance slow wave sleep and memory in cognitively healthy older adults and in those with amnestic mild cognitive impairment.
Alzheimer's disease is a degenerative disorder associated with aging and presents a
significant human and financial burden. Amnestic mild cognitive impairment (aMCI) is a
disorder of impaired memory and is a precursor to Alzheimer's disease. Current treatments are
symptomatic and do not slow disease progression. There is increasing evidence linking sleep
and cognition, such that decreased sleep, particularly slow wave sleep (physiologically slow
wave activity; SWA), is associated with impaired cognitive performance. Not only does SWA
decrease with aging, it is much less in people with aMCI than cognitively normal elderly.
Interventions that improve sleep may also improve cognition. Auditory stimulation using
sounds played through headphones or speakers during sleep have been shown to increase SWA and
memory in young adults. Because this method plays sounds at fixed intervals, its ability to
enhance SWA may be limited. Investigators have developed an improved method that measures
slow waves during sleep in real time and delivers the sound at a particular phase of the slow
wave (phase locked loop; PLL). Given that people with aMCI have low SWA, this method may be
able to improve cognition by enhancing SWA. Our objective is to determine whether the PLL
method of auditory stimulation can increase SWA and improve cognition in people with aMCI.
Investigators propose a randomized sham-controlled cross-over study of auditory stimulation
that population.
The specific aims are:
1. to determine a dose and duration of stimulation required to increase SWA by 10% in
people with aMCI;
2. to determine the effect of the stimulus on cognitive performance in people with aMCI
using word pair recall and the NIH Toolbox cognitive battery, which includes tests in
multiple cognitive domains.
Investigators will recruit 15 participants with aMCI identified through the Northwestern
University Cognitive Neurology and Alzheimer's Disease Center Clinical Core. Participants
will undergo 2 separate nights of polysomnography (stimulation and sham) and cognitive
testing on stimulation and sham visits. There will be approximately 1 week between overnight
visits. The order of stimulation and sham will be randomized. Results study will be used to
determine the optimal stimulation parameters, provide preliminary data on its potential
effect, and guide design of future studies.
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