Mild Cognitive Impairment Clinical Trial
Official title:
Neurotrack Test Validation Protocol
This protocol describes a study to validate Neurotrack's visual paired comparison task, aimed at early detection and monitoring of memory impairment. The investigators will determine whether the novel task developed by Neurotrack is associated with markers of brain pathology associated with very early Alzheimer's disease. The elderly subjects studied will be cognitively normal (CN) or have amnestic mild cognitive impairment (aMCI). For the current study, the primary brain pathology parameters will be derived from MRI scans. Data from this study will be correlated with data from a parallel study designed to validate a larger group of new cognitive tasks by correlating test performance with a broader array of biomarkers of Alzheimer's disease.
The Neurotrack test has the potential to dramatically alter the current methods used for
detecting cognitive deficits. Patients and research subjects could be screened for medial
temporal lobe (MTL) impairment using inexpensive, widely available, safe, and non-invasive
technology.
Subjects will be elderly individuals who are participating in ongoing research at the NYU
Alzheimer's Disease Center (ADC) and who have received the standard ADC clinical evaluation
within the past year, including a medical-neurological evaluation, neuro-psychological
assessment and structural neuroimaging (MRI). As part of the current study, all subjects will
receive both the Neurotrack Visual Paired-Comparison (VPC) Task and MRI scans. The current
protocol strictly for a research study and there will be no "standard care" provided.
Participants will be asked to come in for two separate sessions. The first session will
involve screening to confirm eligibility and administration of the cognitive testing
procedures, while the second session will involve the MRI protocol.
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