Effectiveness of Computerized Cognitive Training in the Elderly With Cognitive Impairment

Mild Cognitive Impairment Clinical Trial

— CoCoTA  

Official title:

Effectiveness of Computerized Cognitive Training Apparatus (CoCoTA) in the Elderly With Normal Cognition, Subjective Cognitive Impairment, Mild Cognitive Impairment

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02480738
• Other study ID #: 10035434
• Status: Completed
• Phase: N/A
• Start date: June 2012
• Est. completion date: July 2013

Study information

• Verified date: May 2019
• Source: Seoul National University Bundang Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study is to investigate the effectiveness of computerized cognitive training, and corresponding neural substrates through multimodal neuroimaging assessment, in the elderly with normal cognition, subjective cognitive impairment, and mild cognitive impairment.

Description:

Computerized cognitive training has the advantage of easy accessibility for community-dwelling elderly. It can be much cheaper than traditional neuropsychological training methods, which require trained neuropsychologists. Furthermore, it may be more fun and easier to be optimized to an individual patients' cognitive status than other traditional methods.

Clinical efficacy of these kinds of cognitive training applications has been validated through several studies. A recent systematic review reported that the domains of working memory, executive function, and processing speed benefited the most by classic computerized cognitive training tasks, and that these benefits were comparable with traditional cognitive training methods. Apart from neuropsychological data, neuroimaging studies focusing on the effectiveness of computerized cognitive training are scant.

There have been no previous studies investigating the possible neural substrates of computerized cognitive training using multimodal neuroimaging modalities simultaneously. Thus, we aimed to investigate the effectiveness of computerized cognitive training and corresponding neural substrates in subjects with mild cognitive impairment, subjective memory impairment, and normal controls through a multimodal approach.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 26
• Est. completion date: July 2013
• Est. primary completion date: April 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 51 Years to 70 Years

Eligibility

Inclusion Criteria:

• Ages >50 to =70

• Years of education = 6 years

• No physical barrier preventing the dominant hand from using the computer mouse

Exclusion Criteria:

• Subjects who had any structural lesions or psychiatric disorders that explained the memory deficits

• Subjects had to be able to undergo pre- and post-training evaluations such as electroencephalography (EEG), FDG-PET, and magnetic resonance imaging (MRI)

• Subjects who had scalp lesions, severe back pain, or claustrophobia that precluded pre- and post-training evaluations.

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Mild Cognitive Impairment

Intervention

Behavioral:
• Computerized Cognitive Training Apparatus
CoCoTA was developed through collaborative research with the Korean Institute of Science and Technology (KIST) and Primpo Co. Ltd. (www.primpo.com). It was designed to stimulate numerous cognitive domains simultaneously by using sounds and objects familiar to Korean elderly. Training themes and scenarios were developed and evaluated by six board-certified neurologists and three neuropsychologists who specialize in dementia. Each subject participated in a total of 24 sessions of cognitive training, which consisted of 40 minutes of training, twice per week. To assure the consistency of cognitive training, trained personnel stayed nearby the subjects to help throughout the training process.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Seoul National University Bundang Hospital

References & Publications (1)

Na HR, Lim JS, Kim WJ, Jang JW, Baek MJ, Kim J, Park YH, Park SY, Kim S. Multimodal Assessment of Neural Substrates in Computerized Cognitive Training: A Preliminary Study. J Clin Neurol. 2018 Oct;14(4):454-463. doi: 10.3988/jcn.2018.14.4.454. Epub 2018 J — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Clinical improvement in the follow-up neuropsychological tests	changes in memory and frontal domain subscores between the baseline and follow-up	12 weeks
Secondary	Cortical thickness changes between baseline and follow-up volumetric MRI	surface-based morphometry using freesurfer software	12 weeks
Secondary	White matter integrities changes between baseline and follow-up diffusion tensor imaging	tract-based spatial statistics using fsl software	12 weeks
Secondary	Spectral ratio changes between baseline and follow-up EEG	EEG spectral ratio analysis	12 weeks
Secondary	local activation pattern changes between baseline and follow-up Fludeoxyglucose PET	local activation pattern analysis using SPM	12 weeks