Cognitive Training and Practice Effects in Mild Cognitive Impairment

Mild Cognitive Impairment Clinical Trial

Official title:

Cognitive Training and Practice Effects in Mild Cognitive Impairment

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02301546
• Other study ID #: R01AG045163
• Secondary ID: R01AG045163
• Status: Completed
• Phase: N/A
• Start date: March 2015
• Est. completion date: February 28, 2020

Study information

• Verified date: May 2020
• Source: University of Utah
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The current study will test the effectiveness of a computerized cognitive training program on auditory memory and attention in patients with mild cognitive impairment. Practice effects will also be examined as a moderator of treatment response.

Description:

The current study will test the effectiveness of a computerized cognitive (thinking) training program on improving thinking and memory in patients with mild cognitive impairment. The investigators will also examine how short term changes in thinking abilities (i.e., practice effects) can be related to improvement in thinking abilities after the cognitive training program.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 197
• Est. completion date: February 28, 2020
• Est. primary completion date: January 28, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• Mild Cognitive Impairment, amnestic subtype

• 65 years of age or older

• Availability of a knowledgeable informant

• Access to internet 3 hours per week

• Adequate vision, hearing, and motor responding to participate in training

Exclusion Criteria:

• History of major stroke, head injury with loss of consciousness of >30 minutes, or other neurological disorder or systemic illness that are thought to be affecting cognition (e.g., seizure disorder, demyelinating disorder, etc.)

• Current or past major psychiatric illness (e.g., schizophrenia, bipolar affective disorder)

• History of substance abuse

• Current use of antipsychotics or anticonvulsant medications

• Currently residing in a nursing home or other skilled nursing facility

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Mild Cognitive Impairment

Intervention

Behavioral:
• computerized cognitive exercises
Each group will perform computerized cognitive exercises, 1 hour per day, 3 - 5 days per week, for 13 weeks. The experimental group will use exercises shown to improve cognition, whereas the comparator group will use exercises without clear beneficial findings.

Locations

Country	Name	City	State
United States	University of Utah Center for Alzheimer's Care, Imaging and Research	Salt Lake City	Utah

Sponsors (2)

Lead Sponsor	Collaborator
University of Utah	National Institute on Aging (NIA)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Auditory Memory Attention Index	This is a composite of six subtests of the Repeatable Battery for the Assessment of Neuropsychological Status. It is a standard score (mean=100, standard deviation=15), with a range of approximately 45 - 145, with higher scores indicating better outcome.	13 weeks