Mild Cognitive Impairment Clinical Trial
Official title:
Effects of Exercise Training in Patients With Mild Cognitive Impairment
The proposes of this study are
1. To understand the physical activities of patients with cognitive impairment in Taiwan
and construct the validity and reliability of the physical activity questionnaire and
actigram in this population.
2. To understand the relation between brain structure (brain tractography and resting
state functional MRI) and cognitive and physical functions of patients with cognitive
impairment, the capability of activity and social engagement (including quality of
life).
3. To understand the efficacy of exercise on the brain structure (brain tractography and
resting state functional MRI), cognitive and physical functions, the capability of
activity and social engagement (including quality of life) of the patients with
cognitive impairment.
The study aims to establish the data base of physical activity of patients with cognitive
impairment in Taiwan. We will also analyze the efficacy of exercise with ICF model on
physical function, physical activity and social engagements to provide an optimized design
of exercise program for patients with cognitive impairment in the future.
There is already evidence that exercise training can delay the progression of dementia. But
if the same effect could be seen in patients with cognitive impairment remains unknown.
There is an increasing importance of how to delay or prevent the turn over of cognitive
impairment patients into dementia in recent years. Thus we propose to investigate the
following issues.
1. To understand the physical activities of patients with cognitive impairment in Taiwan
and construct the validity and reliability of the physical activity questionnaire and
actigram in this population.
2. To understand the relation between brain structure (brain tractography and resting
state functional MRI) and cognitive and physical functions of patients with cognitive
impairment , the capability of activity and social engagement (including quality of
life).
3. To understand the efficacy of exercise on the brain structure (brain tractography and
resting state functional MRI), cognitive and physical functions, the capability of
activity and social engagement (including quality of life) of patients with cognitive
impairment.
The study is a cross sectional study. We recruited 40 cognitive impairment patients from the
memory clinic at National Taiwan University Hospital and another 20 healthy controls matched
for age and gender. We collected the actigram and physical activity from questionnaire for 7
days and performed the analysis for reliability and validity. We will do correlation
analysis with the data with resting state functional MRI and tractography, brain
connectivity, and plasma Aβ1-40 and Aβ1-42 amyloid protein.
The study aims to establish the data base of physical activity of patients with cognitive
impairment in Taiwan. We will also analyze the efficacy of exercise with ICF model on
physical function, physical activity and social engagements to provide an optimized design
of exercise program for patients with cognitive impairment in the future.
;
Observational Model: Case Control, Time Perspective: Cross-Sectional
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