Mild Cognitive Impairment Clinical Trial
Official title:
Phase 1 Study of Cognitive Activation Behavioral Therapy for MCI: A Randomized Waitlist-Control and Delayed Active-Control Study
Mild cognitive impairment (MCI) describes an initial phase of cognitive decline, usually
among older adults, in which a person notices a decline in attention or memory, and performs
worse than normal on cognitive tests of such. People with MCI are more likely to develop
Alzheimer's disease or related dementia than others their same age, and so MCI is thought of
as an early warning sign of progressive cognitive decline.
While some forms of MCI may be brought about by purely genetic causes, other cases may be
due to a withdrawal of cognitive engagement with the world. In these cases, a rigorous
program of cognitive training may be beneficial, halting or reversing symptom progression.
The current study will evaluate a multifaceted cognitive activation program on older adults
with MCI. This group program is intensive, running for 10 weeks, 3 times per week, for a
total of 100 hours of training. Training consists of meditation exercises for broad
attention activation, Tai Chi exercises to integrate cognition with body awareness, and
cognitive training through computerized attention, memory, and problem solving exercise.
Subjective impressions and objective measures of cognitive ability will be measured before
and after the intervention. The investigators will also examine effects on mood and levels
of daily function. Results will be compared to a waitlisted control group. The control group
will subsequently be entered into a home-based version of the program for 10 weeks, with
assessment before and after training, to look at the importance of the group meeting dynamic
in promoting cognitive change.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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