Analysis of Motor Skills in Subjects Aged 55 and Over: the Role of Cognitive Abilities for Planning Movement.

Mild Cognitive Disorder Clinical Trial

— Vieillissement  

Official title:

Analysis of Motor Skills in Subjects Aged 55 and Over: the Role of Cognitive Abilities for Planning Movement.

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04754906
• Other study ID #: MANCKOUNDIA 2018
• Status: Recruiting
• Start date: January 25, 2021
• Est. completion date: December 2025

Study information

• Verified date: December 2023
• Source: Centre Hospitalier Universitaire Dijon
• Contact: Patrick MANCKOUNDIA
• Phone: 0380293970
• Email: patrick.manckoundia[@]chu-dijon.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Falling is an event that is more frequent and severe in older age. It can lead to a loss of autonomy and a decrease in quality of life. It is therefore important to understand this phenomenon in order to better prevent it. Among the multiple risk factors associated with falling, recent research has shown a link between the decline in cognitive abilities (i.e., the mental processes that form our knowledge, such as memory) and the risk of falling. However, the impact of this cognitive decline on motor skills is still poorly understood. The purpose of this research is to study how the changes induced by aging affect motor skills. This would make it possible to take a new look at the phenomenon of falls occurring in the elderly and, in the long term, to improve the prevention and rehabilitation.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 684
• Est. completion date: December 2025
• Est. primary completion date: December 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Neurotypical subjects group:

• Person aged 18 to 40 years

• Person who has given oral consent

• Affiliated to national health insurance

• Right-handed person

2. Group of elderly neurotypical subjects:

• Person over 55 years of age

• Person who has given oral consent

• Affiliated to national health insurance

• No cognitive problems (MMSE score >26)

• Right-handed person

3. Elderly mild cognitive disorder subject group:

• Person over 55 years of age

• Person who has given oral consent

• Diagnosis of Mild Cognitive Disorder made by a neurologist at the Centre Mémoire Ressources et Recherche (CMRR) of the University Hospital of Dijon, following the recommendations of the National Institute for Aging and Alzheimer's Association (Albert et al., 2011) This diagnosis is based on psychometric tests, brain imaging and the evolution of cognitive disorders, including an MMSE test.

• Right-handed person

Exclusion Criteria:

• Neurological or psychiatric history with the exception of the TCL group.

• Follow-up of drug treatment in the last three months that may affect cognitive and/or motor skills.

• Received a shoulder prosthesis on the dominant side.

• Received a hip and/or knee replacement less than a year ago.

• Disabling joint disease of the hip or knee shoulder

• Protected adults (curatorship, guardianship)

• Person deprived of their liberty b judicial or administrative decision

• Pregnant, parturient or breastfeeding woman

• Major unable to consent

Related Conditions & MeSH terms

• Cognition Disorders
• Cognitive Dysfunction
• Mild Cognitive Disorder

Intervention

Other:
• Sequence 1
perform arm movements towards a target
• Sequence 2
judge the verticality of an object
• Sequence 3
In standing position, point as quickly as possible with the right arm at the diode that will light up in front of the participant.

Locations

Country	Name	City	State
France	Chu Dijon Bourgogne	Dijon

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire Dijon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Sequence 1: symmetry ratio of the finger speed profile		through study completion, an average of 3 years
Primary	Sequence 2 : perception bias (error in degrees of angle) of dynamic subjective visual vericality		through study completion, an average of 3 years
Primary	Sequence 3 : activation time of the focal muscles in relation to the postural muscles		through study completion, an average of 3 years