Migraines Clinical Trial
Official title:
Pain Processing in Adults With Migraines
Primary Objective of this study: To assess experimental heat pain responses (pain intensity,
pain unpleasantness, pain catastrophizing, emotional reactivity) in migraineurs vs. healthy
controls.
The current tools of migraine pain measurement are inadequate to distinguish the overall
burden of suffering, as there is an over reliance on a single numerical pain score to
represent the entire pain experience. Measuring and targeting the affective component, in
addition to the sensory component of pain, may capture this discrepancy in disease burden.
The affective component of migraine pain may be just as important as the sensory component to
target and measure since it significantly impacts outcomes, disability, and has therapeutic
treatment implications.
Quantitative sensory testing (QST) is a robust lab paradigm (not a clinical experience) that
delivers one painful noxious thermal stimuli and asks for simultaneous pain intensity and
pain unpleasantness scores. By using this in the research, investigators will be able to
differentiate the sensory (pain quality—what the pain feels like) from the affective (how
awful/unpleasant the pain feels) components of experimental pain in normal controls vs.
migrainuers.
No previous studies have evaluated differences in experimental pain intensity vs. pain
unpleasantness in migraineurs vs. controls. As migraine pain uniquely involves many altered
sensory phenomenon (e.g., photophobia, phonophobia), it cannot be assumed that responses to
experimental pain in migraine will be the same as other clinical pain syndromes. Further,
different clinical pain syndromes have distinct responses to pain intensity vs. pain
unpleasantness.
Investigators will conduct a cross-sectional study in migraineurs (interictally, i.e., between migraine attacks) and healthy controls to compare responses to experimental heat pain intensity and unpleasantness and correlate these results to differences in emotional reactivity and pain catastrophizing. ;
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