Migraine Clinical Trial
Official title:
Hormonal Effects of Puberty-Related Alterations on Pain in Adolescents With Migraine
The purpose of this research study is to investigate the relationships between sex hormone levels and experimental pain sensitivity and migraine severity will be examined.
This study will investigate how puberty and variability in sex hormone levels impact pain sensitivity and migraine symptoms. Hypothesis 1- A significant reduction in pain sensitivity from early to late pubertal status will be found only for adolescents without but not with migraine during pubertal maturation. Hypothesis 2- Experimental pain sensitivity will be negatively correlated with testosterone levels in adolescents in both groups (with and without migraine). Exploratory Hypothesis 1- In adolescents with migraine, higher migraine severity (headache frequency and migraine disability) will be associated with lower testosterone levels. Exploratory hypothesis 2- Adolescents with migraine will have lower testosterone levels than those without. ;
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