Familial and Environmental Factors Behind Migraine

Migraine Clinical Trial

Official title:

Familial and Environmental Factors Behind Migraine

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04356079
• Other study ID #: FEFM
• Status: Not yet recruiting
• Start date: April 2020
• Est. completion date: August 2020

Study information

• Verified date: April 2020
• Source: Assiut University
• Contact: Amal Tohamy, MD
• Phone: 00201221783835
• Email: tohamy.amal[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Migraine is a chronic neurological disease characterized by recurrent moderate to severe headaches often in association with a number of autonomic nervous system symptoms. Migraines are believed to be due to a mixture of environmental and genetic factors. About two-thirds of cases run in families. Changing hormone levels may also play a role, as migraines affect slightly more boys than girls before puberty, but about two to three times more women than men after puberty. The risk of migraines usually decreases during pregnancy. The exact mechanisms of migraine are not known. It is, however, believed to be a neurovascular disorder. The primary theory is related to increased excitability of the cerebral cortex and abnormal control of pain neurons in the trigeminal nucleus of the brainstem.

Description:

Environmental influences play a role, but family studies suggest that defective genes may be primarily involved in disease causation. The mode of transmission of typical migraine in families is still unclear, but it is widely believed to be multifactorial although a role for a major susceptibility gene cannot be excluded. Aim of study: we aim to study the familial risk for developed migraine and its relation to EEG changes.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 80
• Est. completion date: August 2020
• Est. primary completion date: August 2020
• Gender: All
• Age group: 15 Years to 45 Years

Eligibility

Inclusion Criteria:

• Fullfilled Migraine chriteria

Exclusion Criteria:

• Genereal Neurologic Disease

Related Conditions & MeSH terms

• Migraine
• Migraine Disorders

Intervention

Diagnostic Test:
• International Headache Society Test
Thorough History of Patients and families

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Diagnosis of risk factors for migraine	Familial History	6 months