Migraine Clinical Trial
Official title:
Comparison of Therapeutic Effects of Greater Occipital Nerve Block, Topiramate, and Flunarizine on Episodic Migraine: A Randomised Parallel Group Study
Background: Preventive drug therapy in migraine aims to reduce the attack frequency, severity
and duration of headache. Flunarizine and topiramate are widely used in the prevention of
migraine attacks. Greater occipital nerve block (GONB) is an alternative treatment option for
the prophylactic treatment of migraine. In this study, investigators compared the
effectiveness of GONB, topiramate, and flunarizine in terms of reduction in post-treatment
VAS scores and attack frequencies in patients with episodic migraine in a four-week period.
Material and Methods: At least one hundred and twenty migraine patients are aimed to be
randomly divided into three treatment groups, namely flunarizine (n=40, estimated),
topiramate (n=40, estimated) and GONB (n=40, estimated). The patients will be followed up for
four weeks and the attack frequencies and VAS scores will be recorded weekly. At the end of
the fourth week, the response rates based on 50% and 75% or more reduction in the VAS scores
and attack frequencies will be calculated. Group-wise comparisons will be assessed
statistically.
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