Oxygenation and Perfusion in Patients With Acute Migraine Attacks

Migraine Clinical Trial

— OPAMA  

Official title:

Oxygenation and Perfusion in Patients With Acute Migraine Attacks

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03536936
• Other study ID #: Migraine Brain Perfusion
• Status: Completed
• Start date: January 1, 2010
• Est. completion date: April 30, 2018

Study information

• Verified date: May 2018
• Source: University Hospital Inselspital, Berne
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of the study is to retrospectively evaluate brain perfusion and oxygenation in acute migraine attacks. Magnetic resonance perfusion and susceptibility weighted imaging are the technics to measure perfusion and oxygenation respectively.

Description:

The aim of the study is to demonstrate a possible correlation between areas of hypoperfusion and prominent cortical veins during migraine attacks.

These focal ares of altered vascular supply of the brain will be evaluated for correlation with topograhy of symptoms.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1000
• Est. completion date: April 30, 2018
• Est. primary completion date: April 30, 2018
• Gender: All
• Age group: 6 Years to 80 Years

Eligibility

Inclusion Criteria:

final clinical diagnosis of migraine

Exclusion Criteria:

brain tumors, seizures/epilepsy, confirmed cerebral infarct from cerebral atery occlusion, sinus vein thrombosis;

Related Conditions & MeSH terms

• Migraine
• Migraine Disorders
• Migraine with Aura
• Migraine; Status

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital Inselspital, Berne

References & Publications (9)

Bosemani T, Burton VJ, Felling RJ, Leigh R, Oakley C, Poretti A, Huisman TA. Pediatric hemiplegic migraine: role of multiple MRI techniques in evaluation of reversible hypoperfusion. Cephalalgia. 2014 Apr;34(4):311-5. doi: 10.1177/0333102413509432. Epub 2 — View Citation

Charles A, Brennan KC. The neurobiology of migraine. Handb Clin Neurol. 2010;97:99-108. doi: 10.1016/S0072-9752(10)97007-3. — View Citation

Fedak EM, Zumberge NA, Heyer GL. The diagnostic role for susceptibility-weighted MRI during sporadic hemiplegic migraine. Cephalalgia. 2013 Nov;33(15):1258-63. doi: 10.1177/0333102413491027. Epub 2013 Jun 13. — View Citation

Floery D, Vosko MR, Fellner FA, Fellner C, Ginthoer C, Gruber F, Ransmayr G, Doerfler A, Uder M, Bradley WG. Acute-onset migrainous aura mimicking acute stroke: MR perfusion imaging features. AJNR Am J Neuroradiol. 2012 Sep;33(8):1546-52. doi: 10.3174/ajn — View Citation

Förster A, Wenz H, Kerl HU, Brockmann MA, Groden C. Perfusion patterns in migraine with aura. Cephalalgia. 2014 Oct;34(11):870-6. doi: 10.1177/0333102414523339. Epub 2014 Feb 19. — View Citation

Kao HW, Tsai FY, Hasso AN. Predicting stroke evolution: comparison of susceptibility-weighted MR imaging with MR perfusion. Eur Radiol. 2012 Jul;22(7):1397-403. doi: 10.1007/s00330-012-2387-4. Epub 2012 Feb 10. — View Citation

Launer LJ, Terwindt GM, Ferrari MD. The prevalence and characteristics of migraine in a population-based cohort: the GEM study. Neurology. 1999 Aug 11;53(3):537-42. — View Citation

Mourand I, Menjot de Champfleur N, Carra-Dallière C, Le Bars E, Roubertie A, Bonafé A, Thouvenot E. Perfusion-weighted MR imaging in persistent hemiplegic migraine. Neuroradiology. 2012 Mar;54(3):255-60. doi: 10.1007/s00234-011-0946-z. Epub 2011 Aug 11. — View Citation

Planche V, Chassin O, Leduc L, Regnier W, Kelly A, Colamarino R. Sturge-Weber syndrome with late onset hemiplegic migraine-like attacks and progressive unilateral cerebral atrophy. Cephalalgia. 2014 Jan;34(1):73-7. doi: 10.1177/0333102413505237. Epub 2013 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Focal cerebral hypoperfusion and elevated oxygenation in acute migraine attack	Focal cerebral hypoperfusion and elevated oxygenation in acute migraine attack, measured with visual scores on imaging, using a consensus between two readers	Patients, who are admitted to hospital, undergo magnetic resonance imaging within 5 days of migraine attack; time frame: symptoms to imaging : 5 days;