Functional MRI and MRA in Migraine With Aura

Migraine With Aura Clinical Trial

Official title:

Functional MRI and MRA in Migraine With Aura

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01388894
• Other study ID #: MA-01
• Status: Recruiting
• Phase: N/A
• First received: July 5, 2011
• Last updated: July 5, 2011
• Start date: December 2010

Study information

• Verified date: May 2011
• Source: Glostrup University Hospital, Copenhagen
• Contact: Anders Hougaard, MD
• Phone: +4538632713
• Email: andhou05[@]glo.regionh.dk
• Is FDA regulated: No
• Health authority: Denmark: The Regional Committee on Biomedical Research EthicsDenmark: Danish Dataprotection Agency
• Study type: Observational

Clinical Trial Summary

Patients who report that exposure to bright light or strenuous physical activity will induce migraine aura will be provoked using one or both of these methods. Followingly the patients will be examined by functional MRI. Íf the patients develop migraine headache, MR angiography will be performed as well. The primary study hypothesis is that the functional MRI signal will show features similar to those of the electrophysiological phenomenon of cortical spreading depression.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 80
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Diagnosed with migraine with aura as defined by The International Classification of Headache Disorders 2

• Age between 18 and 80 years both inclusive

• Reports that bright light or strenuous physical activity may trigger migraine aura

Exclusion Criteria:

• Contraindications towards exposure to photostimulation or strenuous exercise

• Body weight above 130 kg

• Pregnant or lactating females

• Contraindications towards MRI scanning

• History or clinical signs of: cardiovascular disease, psychiatric disease, substance abuse or any symptom or disease considered relevant by the examining physician.

Study Design

Observational Model: Case-Crossover, Time Perspective: Prospective

Related Conditions & MeSH terms

• Migraine Disorders
• Migraine with Aura

Locations

Country	Name	City	State
Denmark	Danish Headache Center	Glostrup

Sponsors (1)

Lead Sponsor	Collaborator
Glostrup University Hospital, Copenhagen

Country where clinical trial is conducted

Denmark,