Prenatal Diagnosis of Antenatal Midgut Volvulus: Specific Ultrasound Features

Midgut Volvulus Clinical Trial

Official title:

Prenatal Diagnosis of Antenatal Midgut Volvulus: Specific Ultrasound Features

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03362450
• Other study ID #: RECHMPL17_0321
• Status: Completed
• Phase: N/A
• First received: October 25, 2017
• Last updated: December 4, 2017
• Start date: January 1, 2006
• Est. completion date: September 30, 2017

Study information

• Verified date: October 2017
• Source: University Hospital, Montpellier
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Objective:

The small bowel volvulus is a rare cause of intestinal obstruction which may occur in utero and whose prenatal diagnosis is difficult.Sonographic signs are mainly indirect and non specific.The aim of this study is to present a retrospective analysis of prenatal sonographicfindings in fetal segmental midgut volvulus.Thanks to this series the investigators could highlight the more specifics signs of the volvulus included a new pattern.

Description:

Objective:

The small bowel volvulus is a rare cause of intestinal obstruction which may occur in utero and whose prenatal diagnosis is difficult. Sonographic signs are mainly indirect and nonspecific. The aim of this study is to present a retrospective analysis of prenatal sonographic findings in fetal segmental midgut volvulus. Thanks to this series the investigators could highlight the more specifics signs of the volvulus included a new pattern.

Methods:

Unicentric retrospective analysis of cases of prenatal midgut volvulus between 2006 and 2017. The primary inclusion criteria was postnatal diagnosis of prenatal volvulus based on post-natal findings and prenatal imaging findings. The exclusion criteria was the absence of prenatal imaging assessment. The investigators collected the clinical history and the echographic mode B and color Doppler. They have searched for some specific sign like " whirlpool sign " representing the winding of the mesenteric vein around the superior mesenteric arterywith color Doppler with arciform pattern of the midgut, hydro-meconium level in the dilated loops and position of mesenteric vessels for evaluation of the intestinal (mal) rotation. Gold standard was surgery or foetopathology if performed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 13
• Est. completion date: September 30, 2017
• Est. primary completion date: July 1, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• postnatal diagnosis of prenatal volvulus based on post-natal findings and prenatal imaging findings

Exclusion Criteria:

• the absence of prenatal imaging assessment

Related Conditions & MeSH terms

• Digestive System Abnormalities
• Fetal Volvulus
• Intestinal Volvulus
• Midgut Volvulus

Intervention

Other:
• Fetal ultrasound during the second or third trimester/ Postnatal surgery / Post mortem examination
Fetal ultrasound during the second or third trimester Postnatal surgery Post mortem examination

Locations

Country	Name	City	State
France	Uhmontpellier	Montpellier

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Montpellier

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	echography	Observation of specific signs using echography for the diagnosis of fetal during the second (22-24 weeks) and the third (31-34 weeks) trimester after ultrasound screening and when diagnostic ultrasound were performedmidgut volvulus	during the second (22-24 weeks) after ultrasound screening
Primary	echography	Observation of specific signs using echography for the diagnosis of fetal	the third (31-34 weeks) trimester after ultrasound screening
Secondary	ultrasound signs of complication	Observation of ultrasound signs of complication of midgut volvulus during the pregnancy like meconial pseudocyst, ascites, meconial peritonitis.	the third (31-34 weeks) after ultrasound screening
Secondary	ultrasound signs of complication	Observation of ultrasound signs of complication of midgut volvulus during the pregnancy like meconial pseudocyst, ascites, meconial peritonitis.	during the second (22-24 weeks) after ultrasound screening
Secondary	ultrasound signs of complication	Observation of ultrasound signs of complication of midgut volvulus during the pregnancy like meconial pseudocyst, ascites, meconial peritonitis after diagnostic ultrasound.	1 day
Secondary	ultrasound signs of complication	Observation of ultrasound signs of complication of midgut volvulus during the pregnancy like meconial pseudocyst, ascites, meconial peritonitis.	just after delivery
Secondary	presence or not of the volvulus	Observation of surgery outcome like presence or not of the volvulus after diagnostic ultrasound	1 day
Secondary	presence or not of the volvulus	Observation of surgery outcome like presence or not of the volvulus	during the second (22-24 weeks) after ultrasound screening
Secondary	presence or not of the volvulus	Observation of surgery outcome like presence or not of the volvulus	just after delivery
Secondary	presence or not of the volvulus	Observation of surgery outcome like presence or not of the volvulus	the third (31-34 weeks) after ultrasound screening
Secondary	presence or not ileal atresia.	Observation of surgery outcome like presence or not ileal atresia	during the second (22-24 weeks) after ultrasound screening
Secondary	presence or not ileal atresia.	Observation of surgery outcome like presence or not ileal atresia	the third (31-34 weeks) after ultrasound screening
Secondary	presence or not ileal atresia.	Observation of surgery outcome like presence or not ileal atresia	just after delivery
Secondary	presence or not ileal atresia.	Observation of surgery outcome like presence or not ileal atresia after diagnostic ultrasound	1 day