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Microvascular Rarefaction clinical trials

View clinical trials related to Microvascular Rarefaction.

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NCT ID: NCT06098300 Recruiting - Clinical trials for Arterial Hypertension

Effects of Change in Blood Pressure on Retinal Capillary Rarefaction in Patients With Arterial Hypertension

Start date: September 1, 2023
Phase:
Study type: Observational

To evaluate whether in patients with initially poorly-controlled arterial hypertension, structural and functional differences in the retina and choroid remain after achieving a well-controlled blood pressure.

NCT ID: NCT05728047 Recruiting - Clinical trials for Heart Valve Diseases

Evaluation of Systemic Microcirculation of Patients Undergoing Heart Valve Surgery

Start date: September 10, 2022
Phase:
Study type: Observational

The study aims to study the systemic microcirculation in adult patients hospitalized at a quaternary public hospital during the preoperative and immediate postoperative periods of heart valve surgery and correlations to their clinical and laboratory outcomes in the postoperative period.

NCT ID: NCT05464849 Recruiting - Clinical trials for Endothelial Dysfunction

Evaluation of Systemic Microvascular Reactivity in Patients With Resistant Hypertension

Start date: December 20, 2021
Phase:
Study type: Observational

Systemic arterial hypertension is a serious health problem worldwide. In some cases, it can phenotypically present as resistant arterial hypertension, which consists of blood pressure levels outside the treatment goals in patients using three or more classes of antihypertensive drugs, one of which is preferably a thiazide diuretic. Resistant hypertension contributes to a 47% higher risk of developing cardiovascular events when compared to patients with non-resistant hypertension. It is known that the microcirculation plays a relevant role in the pathophysiology of arterial hypertension. Furthermore, it is known that the cutaneous microvascular network is an adequate model and that it reflects the systemic microcirculation. In this sense, the present research proposes the study of cutaneous capillary density - through high resolution intravital microscopy - and of the endothelium-dependent and independent microvascular vasodilator response - by the speckle laser flowmetry method coupled to a pharmacological system of micro- iontophoresis - in patients diagnosed with resistant hypertension, with the aim of identifying changes in comparison with patients with non-resistant hypertension and normotensive individuals. Additionally, the evaluation of the association between systemic microvascular function and the presence of target organ lesions in this population may indicate that this is a new non-invasive way of stratifying cardiovascular risk in these individuals.

NCT ID: NCT04406545 Completed - Clinical trials for Endothelial Dysfunction

Microvascular Flow and Reactivity in Patients Presenting in the Acute Phase of COVID-19.

Start date: May 15, 2020
Phase:
Study type: Observational

Considering that the intensity of systemic microvascular changes in patients in the acute phase of COVID-19 could be related to disease progression and prognosis, the present cross-sectional and observational study aims to investigate the presence of endothelial dysfunction in these patients, also looking for to evaluate associations between the presence of endothelial dysfunction and demographic, clinical and laboratory variables.