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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00663520
Other study ID # Study #3631
Secondary ID
Status Completed
Phase
First received April 18, 2008
Last updated April 16, 2018
Start date January 2008
Est. completion date February 2014

Study information

Verified date April 2018
Source Oregon Health and Science University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to determine if women with chest pain and "clean" heart blood vessels have impaired blood flow to the heart due to problems with the small blood vessels that provide blood and oxygen to the heart. Impairment in the small blood vessels will be tested using ultrasound pictures of the heart, called myocardial contrast echocardiography. Since these small blood vessels are not seen in a coronary angiogram, which is an x-ray of the heart vessels using a dye containing iodine injected in the heart vessels, the problem may remain undiagnosed in women until the heart muscle becomes severely damaged.

A second purpose is to identify if there is a common trait in the population of women with this tiny blood vessel dysfunction, which will be investigated by checking blood levels of certain chemical and hormones related to heart disease. Finally, we would like to investigate the relationship between depression and stress, and heart disease. We will do this by measuring cortisol (a hormone that serves as a measure of stress) and administering questionnaires that help to identify depression and stress.


Description:

Not Available


Recruitment information / eligibility

Status Completed
Enrollment 40
Est. completion date February 2014
Est. primary completion date February 2014
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 45 Years to 75 Years
Eligibility Inclusion Criteria:

- Women 45 to 75 years of age

Exclusion Criteria:

- Pregnancy

- Allergy to any component of the drugs: Definity®. Dipyridamole Aminophyllin or Iodine.

- Known coronary heart disease, significant valvular disease (valvular stenosis or insufficiency greater than moderate) left ventricular systolic dysfunction, congenital heart disease or cardiac shunt, pulmonary hypertension, moderate or severe asthma.

- Inability to reach the patient by mail, fax, e-mail or phone

- Active infection

- Malignancy

- Uncontrolled hypertension

- Smoking

- Severe asthma

- Kidney disease

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
United States Oregon Health and Science University Portland Oregon

Sponsors (1)

Lead Sponsor Collaborator
Oregon Health and Science University

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Elucidating the Role of Microvascular Dysfunction in Heart Disease in Women Data collection 2008-2014
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