Pregnancy Clinical Trial
Official title:
Effect of Micronutrients and Exercise During Pregnancy on Factors Related With Non-Transmissible Chronic Diseases
At the moment, most of efforts to prevent non-transmissible chronic diseases at population
level have been centered in promoting healthful behaviors like physical activity, consumption
of fruits and vegetables, and discouraging from the consumption of tobacco and alcohol in
adult population, but the results have been little hopeful. In the last years, manifold
studies have indicated the relation between metabolic alterations and of the fetal growth
with the development of non-transmissible chronic diseases in adult age. More recently, it
has been proposed that maternal factors (endothelial function, oxidative stress and
alterations in adipokines) and placental ones (mitochondrial dysfunction) are the precursory
mechanisms of fetal metabolic alterations and of the later development of non-transmissible
chronic diseases. Also, it has been suggested that possibly supplementation with
micronutrients and the physical exercise during the gestation can regulate these maternal and
placental factors. For the reasons just mentioned, it is necessary to clarify if these
proposed factors are related to fetal metabolic alterations and if the supplementation during
the gestation with micronutrients and/or the physical exercise can regulate them, which would
be an early and novel alternative to fortify the prevention of non-transmissible chronic
diseases in the population.
Purpose
1. To evaluate the effect of associated both the maternal and placental metabolic factors
to non-transmissible chronic diseases in newborn.
2. To evaluate the effect of the physical exercise and the complementation with
micronutrients during the pregnancy either in the endothelial function, the levels of
adipokines, the oxidative stress of the mother and the newborn, as in the placental
mitochondrial function and the anthropometry of newborn.
Hypothesis:
1. There is correlation between the metabolic factors, related to non-transmissible chronic
diseases, of the mother and those of the newborn one.
2. Supplementation with either micronutrients or physical exercise influence beneficially
as much in the endothelial function, oxidative stress, the levels in adipokines of the
mother and the newborn one like in the placental mitochondrial function.
3. The simultaneous intervention with micronutrients or physical exercise produces an
additional beneficial effect in the metabolic state of the mother and the newborn one.
4. The metabolic alterations when being born are not exclusive of newborn with
anthropometric measures located either in the inferior or superior percentiles.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03442582 -
Afluria Pregnancy Registry
|
||
| Terminated |
NCT02161861 -
Improvement of IVF Fertilization Rates, by the Cyclic Tripeptide FEE - Prospective Randomized Study
|
N/A | |
| Not yet recruiting |
NCT05934318 -
L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE)
|
N/A | |
| Enrolling by invitation |
NCT05415371 -
Persistent Poverty Counties Pregnant Women With Medicaid
|
N/A | |
| Completed |
NCT04548102 -
Effects of Fetal Movement Counting on Maternal and Fetal Outcome Among High Risk Pregnant Woman
|
N/A | |
| Completed |
NCT03218956 -
Protein Requirement During Lactation
|
N/A | |
| Completed |
NCT02191605 -
Computer-delivered Screening & Brief Intervention for Marijuana Use in Pregnancy
|
N/A | |
| Completed |
NCT02223637 -
Meningococcal Quadrivalent CRM-197 Conjugate Vaccine Pregnancy Registry
|
||
| Recruiting |
NCT06049953 -
Maternal And Infant Antipsychotic Study
|
||
| Completed |
NCT02577536 -
PregSource: Crowdsourcing to Understand Pregnancy
|
||
| Not yet recruiting |
NCT06336434 -
CREATE - Cabotegravir & Rilpivirine Antiretroviral Therapy in Pregnancy
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT04786587 -
Alcohol Self-reporting During Pregnancy. AUTOQUEST Study.
|
||
| Not yet recruiting |
NCT05412238 -
Formulation and Evaluation of the Efficacy of Macro- and Micronutrient Sachets on Pregnant Mothers and Children Aged 6-60 Months
|
N/A | |
| Not yet recruiting |
NCT05028387 -
Telemedicine Medical Abortion Service Using the "No-test" Protocol in Ukraine and Uzbekistan.
|
||
| Completed |
NCT02683005 -
Study of Hepatitis C Treatment During Pregnancy
|
Phase 1 | |
| Completed |
NCT02783170 -
Safety and Immunogenicity of Simultaneous Tdap and IIV in Pregnant Women
|
Phase 4 | |
| Recruiting |
NCT02619188 -
Nutritional Markers in Normal and Hyperemesis Pregnancies
|
N/A | |
| Recruiting |
NCT02564250 -
Maternal Metabolism and Pregnancy Outcomes in Obese Pregnant Women
|
N/A | |
| Recruiting |
NCT02507180 -
Safely Ruling Out Deep Vein Thrombosis in Pregnancy With the LEFt Clinical Decision Rule and D-Dimer
|
||
| Completed |
NCT02528136 -
The Clinical Carbetocin Myocardium Trial
|
Phase 4 |