Changes in the Microbiome Associated With Transplantation

Microbiota Clinical Trial

Official title: Changes in the Microbiome Associated With Transplantation

Status Recruiting

Clinical Trial Summary

To study the effects of organ transplantation and immunosuppression on the human microbiome, and to understand the interlinkage of changes in the microbiome with clinical events surrounding transplantation, and graft and patient clinical outcomes.

Clinical Trial Description

This study will involve the collection of oral swabs, saliva, urine and rectal swabs, blood and skin scrapings from patients before and after kidney and pancreas transplantation. At Day 0 and day 1, week 1, and at 3, 6, and 12 months.

These samples will be collected longitudinally over a period of one year after transplantation and will be analysed using 16s rRNA gene sequencing in order to capture the dynamics of the microbiome after exposure to surgery, immunosuppression and the specific medication necessary during the process of transplantation.

Two groups of recipients will be recruited, the first one includes kidney and/or pancreas transplant recipients from both deceased and living donors. ;

Related Conditions & MeSH terms

• Microbiota

• NCT number: NCT04280627
• Study type: Observational
• Source: Manchester University NHS Foundation Trust
• Contact: Titus Augustine, FRCP
• Phone: 0161 2763647
• Email: titus.augustine@mft.nhs.uk
• Status: Recruiting
• Start date: May 24, 2019
• Completion date: December 31, 2025