Microbiome Alterations in IL10RA-deficient Patients After HSCT

Status Terminated

Clinical Trial Summary

To elucidate the longitudinal development of intestinal microbiota in patients with IL10RA deficiency after hematopoietic stem cell transplantation (HSCT). The investigators planned to collect fecal samples from IL10RA-deficient patients who received HSCT. Samples were collected more than once every three days after engraftment in lamina flow ward and at least once a week before discharge. Microbial DNA was extracted from the fecal samples. And all analysis was based on the next generation sequencing data.

Clinical Trial Description

Hematopoietic stem cell transplantation is considered the only curative therapy for patients with interleukin-10 receptor-A(IL10RA) deficiency. The investigators aimed to collect the fecal samples of these patients throughout the conditioning, transplantation until discharge, providing a dense insight into the longitudinal development of intestinal microbiota. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03752372
Study type	Observational
Source	Children's Hospital of Fudan University
Contact
Status	Terminated
Phase
Start date	October 1, 2017
Completion date	February 28, 2020

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