Microbiome & Papillary Thyroid Microcarcinoma

Status Not yet recruiting

Clinical Trial Summary

It has been shown that gut microbiome and microbiome metabolism can regulate or control the initiation of a cancer process. To the best of the investigators knowledge, no study has directly shown the relationship of the thyroid microcarcinoma to the human microbiome. In this work, the aim is to detect the microbiome in peripheral blood in a patient with a thyroid gland carcinoma, and to correlate it with the disease, compared to the microbiome of a group of patients who did not find another thyroid gland carcinoma

Clinical Trial Description

Measurements of biological markers and tumor cell motility may be useful in predicting early whether a papillary thyroid microcarcinoma (PTMC) will develop to invasive carcinoma. Ideally, patients at high risk of progression may undergo immediate surgery instead of active surveillance and those with a very low likelihood of tumor progression may be included in an active surveillance protocol. Future research should focus on the development of new predictive early markers of papillary thyroid carcinoma during patient follow-up. From the above, it is clear the need to develop a new marker that raises the suspicion of possible thyroid microcarcinoma, if it is not preoperatively detected by the needle biopsy method and the patient has the indication for surgery for another benign thyroid disease. To date, there are no absolute biological and clinical parameters distinguishing a low risk from a high risk PTMC. If the fine needle aspiration shows stage V and VI Bethesda classification, and there is a high suspicion of PTMC, then questions such as the extent of the surgery, lobectomy or total thyroidectomy are beginning to be raised. The next dilemma is lymphadenectomy. The dilemma is greater if there are enlarged cervical lymph nodes (diameter over 1 cm in diameter of the small axis) and subsequently micromestases are confirmed. Another entity is when the cervical lymph nodes are not pathologically enlarged. This clinical situation is often emphasized as 60-80% of PTMC patients have metastases. By correlating a possible difference in the microbiome of a participants peripheral blood preoperatively, together with the imaging data, there may have been another marker of early PTMC detection and patient management planning respectively. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04376203
Study type	Observational
Source	University of Ioannina
Contact	STEFANOS STEFANOU, Specialist
Phone	+306944983533
Email	stefanousurgery@gmail.com
Status	Not yet recruiting
Phase
Start date	July 27, 2020
Completion date	May 30, 2023

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT03586622` - One Year Home Monitoring and Treatment of IBS Patients	N/A
Active, not recruiting	`NCT04552834` - Alterations of the Microbiome During Critical Illness With Short and Long Term Clinical Outcomes
Completed	`NCT03201068` - Probiotic Supplement and Microbiome, Immune System and Metabolic Syndrome	N/A
Completed	`NCT04217122` - Effect of Strawberry Consumption on the Microbiome	N/A
Recruiting	`NCT05521295` - Frozen Embryo Transfer Pregnancy Outcomes Prediction by Microbiome
Recruiting	`NCT05545631` - Frozen Embryo Transfer Pregnancy Outcomes Prediction by Microbiome and Transcriptome
Not yet recruiting	`NCT05852145` - Oral Changes With Caloric and no Caloric Sweeteners	Phase 1/Phase 2
Withdrawn	`NCT04099446` - A Non-Interventional Pilot Study to Explore the Skin Microbes in Skin Cancer
Recruiting	`NCT05445544` - A Multicenter Cohort Study on Maternal and Infant Microecology and New Targets for Pre-eclampsia Screening in China
Active, not recruiting	`NCT03213275` - The Premature Gut Microbiome and the Influence on Neonatal Immunity, Brain Development and White Matter Injury
Recruiting	`NCT05505110` - MOdification Of THe Early-Life Respiratory Microbiome Through Vaginal SEEDing	N/A
Completed	`NCT04851340` - Investigating the Detection of Bovine and Soy Proteins in Human Milk	N/A
Completed	`NCT06133400` - Mapping the Health Status of the Population of French Polynesia: the MATAEA Project	N/A
Withdrawn	`NCT04114513` - Dietary Fibers Effect on the Gut Microbiota Composition	N/A
Not yet recruiting	`NCT05612620` - Elucidating the Microbiome in Patients With Recurrent Pregnancy Loss
Completed	`NCT04611945` - Westlake Sailing Cohort
Recruiting	`NCT04260295` - Study of the Correlation of Tumor Tissue Microbiome to the Pathogenesis of Lung Cancer
Completed	`NCT04155684` - Dysbiosis Impact on Lung Disease in HIV
Active, not recruiting	`NCT06424691` - Infant Restore: Efficacy of Microbiome Analysis and Education	N/A
Completed	`NCT05510050` - Comparison Study of Manapol and DaltonMax on Immune Function, Microbiome, and Related Variables in Men and Women	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Microbiome and Papillary Thyroid Microcarcinoma

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms