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NCT ID: NCT04686682 Recruiting - NSCLC Clinical Trials

A First-in-Human, JAB-8263 in Adult Patients With Advanced Tumors

Start date: May 7, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

This is a Phase 1/2a, first-in-human, open-label study of JAB-8263, this study has two parts: solid tumor dose escalation and expansion study and hematology tumor dose escalation and expansion study. These two parts will determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D) and assess the DLT of JAB-8263 in treatment with patients with advanced solid tumors and hematology tumors separately. 30 subjects each will be enrolled.

NCT ID: NCT02469974 Withdrawn - Myelofibrosis Clinical Trials

Ruxolitinib in Combination With Autotransplant

Start date: May 2015
Phase: N/A
Study type: Interventional

To determine the safety of the approach of giving RUXOLITINIB before and after an autologous stem cell transplant, as measured by graft failure or death.