The Use of Isocapnic Hyperventilation (iHV) for Treatment of Methanol Poisoned Patients — iHV-Met  

Methanol Poisoning Clinical Trial

Official title: The Use of Isocapnic Hyperventilation (iHV) for Treatment of Methanol Poisoned Patients

Status Recruiting

Clinical Trial Summary

The projects investigate if treatment with isocapnic hyperventilation can eliminate methanol from the body in a similar manner to dialysis. This is achieved by administering the antidote (fomepizole) and let the patient breathe on a isocapnic hyperventilation device while samples of blood, urine and maybe the breath are collected to measure the contents of methanol and its metabolites.

Clinical Trial Description

Isocapnic hyperventilation (iHV) The normal physiology breathing is a careful balance between the number of breaths per minute (rate/min) and the depth of each breath (tidal volume, Vt). Together they make up the minute ventilation (MV), where MV= rate x Vt). To maintain stable homeostasis in the organism, the minute ventilation is closely regulated to maintain adequate uptake of oxygen and adequate elimination of the carbon dioxide (CO2) that is produced by the metabolism. Too low minute ventilation leads to a buildup of CO2 and decrease in blood pH (respiratory acidosis), while hyperventilation (too high minute ventilation) leads to an excess loss of CO2 and increase in blood pH (respiratory alkalosis). The same mechanism will also enable the organism to compensate any metabolic disturbances (up to a certain point): A metabolic acidosis will be counteracted by a hyperventilation, whereas a metabolic alkalosis will be counteracted by a hypoventilation, both with the ultimate goal of keeping the acidity (as given by the pH) as closely regulated as possible. The concept of isocapnic hyperventilation (iHV) allows the person to hyperventilate while keeping the CO2 within normal limits at the same time. The ClearMate (Thornhill Research Inc., Canada) adds CO2 to the inspired air to compensate to the increased loss induced by the increased minute ventilation. This means that hyperventilation can occur, and a wash-out of volatile substances such as methanol will happen without disrupting the important CO2 balance. ;

Related Conditions & MeSH terms

• Hyperventilation
• Methanol Poisoning
• Poisoning

• NCT number: NCT06173817
• Study type: Interventional
• Source: Oslo University Hospital
• Contact: Knut Erik Hovda, MD, Ph D
• Phone: +4799618356
• Email: knuterikhovda@gmail.com
• Status: Recruiting
• Phase: Phase 2/Phase 3
• Start date: December 20, 2023
• Completion date: June 30, 2026