Deep Brain Stimulation (DBS) for Methamphetamine Use Disorder

Status Recruiting

Clinical Trial Summary

We will evaluate the effects of deep brain stimulation (DBS) of bilateral nucleus accumbens (NAc) added to background treatment for treatment refractory Methamphetamine Use Disorder (MUD). This is a small randomized cross-over study to demonstrate feasibility and safety, test treatment outcomes (use, craving), and identify novel biological targets (NAc local field potentials (LFP) and functional MRI).

Clinical Trial Description

In a randomized cross-over design of DBS of the nucleus accumbens (NAc) for treatment refractory methamphetamine use disorder (MUD, n=5), we will test safety, feasibility, effect on clinical outcomes (craving and use), and seek to identify biological targets (using cue craving during recording of local field potentials and MRI). ;

Study Design

Related Conditions & MeSH terms

Methamphetamine Use Disorder

Clinical Trial Details

NCT number	NCT05558358
Study type	Interventional
Source	University of Colorado, Denver
Contact	Joseph T Sakai, MD
Phone	303-724-7402
Email	joseph.sakai@cuanschtz.edu
Status	Recruiting
Phase	Phase 1/Phase 2
Start date	January 15, 2024
Completion date	February 1, 2025

View Details

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