Effects of Modafinil in Methamphetamine Dependence

Status Completed

Clinical Trial Summary

Methamphetamine dependence is a serious public health problem with no pharmacologic treatments currently available. Relapse rates are high in this population. Exposure to cues previously associated with methamphetamine use may induce profound craving in abstinent individuals. Chronic methamphetamine abuse is associated with selective cognitive deficits that may undermine successful participation in psychosocial treatments. Medications which improve cognitive deficits in methamphetamine-dependent individuals may improve abstinence rates, especially in the critical early period of recovery. Modafinil is an atypical stimulant medication with evidence to support its use in treating cocaine dependence and attention deficit/hyperactivity disorder. The proposed studies are designed to evaluate modafinil as a potential treatment for methamphetamine dependence and its cognitive sequelae.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Methamphetamine Dependence

Clinical Trial Details

NCT number	NCT00751023
Study type	Interventional
Source	Medical University of South Carolina
Contact
Status	Completed
Phase	Phase 4
Start date	February 2009
Completion date	July 2010

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT01813656` - An Study of Aripiprazole in the Treatment of Methamphetamine Dependence	Phase 4
Completed	`NCT00984360` - Study of Naltrexone for Methamphetamine Addiction	Phase 2
Completed	`NCT01685463` - Transcranial Magnetic Stimulation Used to Both Measure Cortical Excitability and Explore Methamphetamine Cue Craving	N/A
Completed	`NCT00569374` - Safety and Tolerability of Modafinil for Methamphetamine Dependence	Phase 2
Completed	`NCT01967381` - Targeting GABA and Opioid Systems for a Pharmacotherapy for Methamphetamine Abuse	Early Phase 1
Completed	`NCT01354470` - A Randomized, Placebo-Controlled Trial of Modafinil for Methamphetamine Dependence	Phase 2
Active, not recruiting	`NCT01044238` - Methylphenidate to Treat Methamphetamine Dependence	Phase 2
Completed	`NCT01215929` - Studying Amphetamine Withdrawal in Humans	Phase 2
Terminated	`NCT01019707` - Safety Assessment of Atomoxetine With MA IV Administration	Phase 1
Completed	`NCT00227123` - A Randomized Control Trial Comparing Quetiapine to Risperidone in Bipolar Disorder With Stimulant Dependence	N/A
Recruiting	`NCT02568878` - Creatine for Depressed Male and Female Methamphetamine Users	Phase 3
Completed	`NCT01011829` - Varenicline vs Placebo for the Treatment of Methamphetamine Dependence	Phase 2
Completed	`NCT01007539` - Efficacy and Safety of CDP-choline in Patients With Methamphetamine Dependence	Phase 3
Completed	`NCT01062451` - An ACE Inhibitor (Perindopril) or an Angiotensin Receptor Blocker (Candesartan) as a Treatment for Methamphetamine Dependence	Phase 1
Completed	`NCT00687713` - Phase 2, Double-Blind, Placebo-Controlled Trial of Bupropion for Methamphetamine Dependence	Phase 2
Completed	`NCT01063205` - NAC as a Potential Treatment for Methamphetamine Dependence	Phase 1
Completed	`NCT02058966` - Pilot Study of Entacapone for Methamphetamine Abuse	Early Phase 1
Completed	`NCT00332605` - N-Acetyl Cysteine Plus Naltrexone in Methamphetamine Dependence	Phase 2
Completed	`NCT01860807` - Trial of Ibudilast for Methamphetamine Dependence	Phase 2
Terminated	`NCT01813643` - A Comparison of Risperidone and Aripiprazole for Treatment of Patirnts With Methamphetamine-Associated Psychosis	Phase 4