Contingency Management for Meth in South Africa Methamphetamine Abuse in South Africa

Methamphetamine Abuse Clinical Trial

Official title:

Combating Craving With Contingency Management: Neuroplasticity and Methamphetamine Abuse in South Africa

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02907853
• Other study ID #: R21CMinSA
• Status: Completed
• Phase: N/A
• Start date: September 1, 2015
• Est. completion date: February 15, 2018

Study information

• Verified date: May 2019
• Source: University of California, Los Angeles
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will link findings from neuroscience with clinical outcomes using contingency management (CM) to identify changes in brain structure and function that emerge during purely behavioral therapy for methamphetamine (MA) use.

Description:

This study will correlate MA-abstinence outcomes from an 8-week program of voucher-based incentives using an escalating schedule for 30 treatment-seeking, MA-dependent individuals with scores on tasks of working memory and assessments of neuropsychological and demographic status. At the beginning and end of the CM program, participants will participate in MRI scans while performing a working memory task and will complete a battery of select neurocognitive and psychological assays to address two specific aims: (1) to determine whether changes in neural function within frontostriatal circuitry from baseline to end of the 8-week CM program are associated with parallel changes in measures of cognitive control and impulsivity and with MA abstinence outcomes and (2) to determine whether structural changes in frontostriatal circuitry over the 8-week CM intervention correspond with neurocognitive, psychological and MA abstinence measures.

Other known NCT identifiers

• NCT02948868

Recruitment information / eligibility

• Status: Completed
• Enrollment: 28
• Est. completion date: February 15, 2018
• Est. primary completion date: February 15, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• provide voluntary informed consent

• meet DSM-5 criteria for MA or amphetamine use disorder

• provide at least one urine sample positive for MA/amphetamine metabolites during screening (i.e. prior to the commencement of the study).

• aged 18-45

• right-handed

• English-speaking

Exclusion Criteria:

• currently receiving treatment for stimulant addiction or needing more intensive treatment than outpatient care

• meet DSM-5 criteria for substance use disorder other than nicotine

• unable to attend 4+ visits during the 2-week screening period or to complete measures

• Physical or mental illness that would require intervention that would alter imaging or that would interfere with safe study participation

• pregnant, claustrophobic, or have metal prostheses, cardiac pacemakers, or metal clips that are incompatible with the scanner

• HIV positive status

• unable to comprehend written or spoken English

• currently taking psychiatric medication

Related Conditions & MeSH terms

• Methamphetamine Abuse

Intervention

Behavioral:
• Contingency Management
as described above

Locations

Country	Name	City	State
South Africa	Department of Psychiatry at Groote Schuur Hospital	Cape Town

Sponsors (2)

Lead Sponsor	Collaborator
University of California, Los Angeles	University of Cape Town

Country where clinical trial is conducted

South Africa, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Responses to Contingency Management	urine samples documenting methamphetamine abstinence	8 weeks
Primary	fMRI Measures	measures of resting state connectivity	Change b/w baseline and 8 Weeks
Secondary	Stop Signal Task	measure of inhibitory control	Change b/w baseline and 8 Weeks
Secondary	Continuous Performance Task	test of sustained attention	Change b/w baseline and 8 Weeks
Secondary	Stroop	test of inhibitory control	Change b/w baseline and 8 Weeks
Secondary	Balloon Analog Risk Task	measure of risk taking and decision making	Change b/w baseline and 8 Weeks