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Efficacy Study of Pembrolizumab With Entinostat to Treat Metastatic Melanoma of the Eye — PEMDAC  

Metastatic Uveal Melanoma Clinical Trial

Official title:
A Multicenter Phase II Open Label Study to Evaluate Efficacy of Concomitant Use of Pembrolizumab and Entinostat in Adult Patients With Metastatic Uveal Melanoma

Clinical Trial Summary

The purpose of this study is to see if the combination of entinostat and pembrolizumab can be an effective treatment for patients with melanoma of the eye (uveal melanoma) that has spread to other sites of the body (metastatic disease). Pembrolizumab is an antibody that helps the immune system to attack cancer cells. Although pembrolizumab has proven clinical efficacy in treating patients with metastatic cutaneous melanoma, an effect on metastatic uveal melanoma has not been established. Entinostat is a histone deacetylase (HDAC) inhibitor that has effects on both cancer cells and immune regulatory cells, thus potentially enhancing the effects of immunotherapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02697630
Study type Interventional
Source Vastra Gotaland Region
Contact
Status Completed
Phase Phase 2
Start date February 21, 2018
Completion date January 31, 2023
View Details
See also
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