18F-FSPG PET/CT for Cancer Patients on Therapy

Status Completed

Clinical Trial Summary

The goal of this phase 2 study trial is to evaluate the utility of the radiolabel 18F-FSPG used before and after treatment to diagnose, predict, and evaluate response to therapy in patients with a wide variety of metastatic cancers.

Clinical Trial Description

OUTLINE:

Patients are evaluated with a PET/CT scan using the radiolabel 18F-FSPG [18F-(S)-4-(3-fluoropropyl)-L-glutamic acid] or 18F-FDG ([18F]-fluorodeoxyglucose), before and after therapeutic treatment.

PRIMARY OBJECTIVE:

Uptake of the radiolabel 18F-FSPG in patients with biopsy-proven cancer will be evaluated and compared to the uptake of 18F-FDG, before and after therapy (non-specified) in the same group of patients.

SECONDARY OBJECTIVES:

- Compare the agreement of the clinical assessment for cancer status between 18F-FSPG and 18F-FDG.

- Safety and tolerability of 18F-FSPG and 18F-FDG. ;

Study Design

Related Conditions & MeSH terms

B-Cell Neoplasm
Breast Neoplasms
Carcinoma, Non-Small-Cell Lung
Carcinoma, Renal Cell
Estrogen Receptor Negative
HER2/Neu Negative
Lung Neoplasms
Lymphoma, B-Cell
Mesothelioma
Metastatic Renal Cell Cancer
Progesterone Receptor Negative
Stage III Mesothelioma
Stage III Renal Cell Cancer
Stage IIIA Breast Cancer
Stage IIIA Non-Small Cell Lung Cancer
Stage IIIB Non-Small Cell Lung Cancer
Stage IIIC Breast Cancer
Stage IV Breast Cancer
Stage IV Mesothelioma
Stage IV Non-Small Cell Lung Cancer
Stage IV Renal Cell Cancer
Triple Negative Breast Neoplasms
Triple-Negative Breast Carcinoma

Clinical Trial Details

NCT number	NCT02599194
Study type	Interventional
Source	Stanford University
Contact
Status	Completed
Phase	Phase 2
Start date	July 2015
Completion date	December 14, 2016

View Details

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