Evaluation of Cognitive Function of Patients With Sunitinib or Sorafenib

Status Completed

Clinical Trial Summary

Patients with advanced kidney cancer or GIST (Gastro Intestinal Stromal Tumor: this is a tumor of the intestines) may be eligible for treatment with one of the following drugs: sunitinib (Sutent ®) or sorafenib (Nexavar ®). These drugs inhibit blood vessel formation in cancer cells. These cancer cells are hampered in their growth. To enlarge the investigators knowledge on the effects and side effects of these two medicines, in the University Medical Center St. Radboud lot of research is done. This study is a part of that.

Patients receiving sunitinib or sorafenib tell sometimes that they feel that they are less able to concentrate, that their memory is not working properly or that they are less able to imagine a solution to a complex problem . Perhaps you recognize these symptoms as well. In how many of the patients this occurs, how severe the symptoms are and how it is caused, is still unknown.

The goal of this research is to examine how memory, concentration and knowledge processing works in patients using sorafenib or sunitinib. With the research the investigators hope to get answers to the following questions:

1. How common are problems with memory, concentration and processing of knowledge in patients receiving the drug sunitinib or sorafenib?

2. What are the problems of memory, concentration and processing of knowledge in the use of sunitinib or sorafenib?

3. What could be the cause of the problems that patients experience from memory, concentration and processing of knowledge in the use of sunitinib or sorafenib?

4. Is there a link between problems with memory, concentration and processing of knowledge and also experiences of fatigue or mood of a patient?

Clinical Trial Description

In this study we will focus on subjective and objective cognitive dysfunctioning in patients with metastatic cancer, treated with sunitinib or sorafenib. In our own clinical practice a substantial part of our patients that are treated with targeted therapies directed against VEGF, mention that they have problems with concentrating and that their memory function is decreased. Relatives sometimes point out that the behaviour of the patient is slightly different than before starting the VEGF (Vascular Endothelial Growth Factor) inhibition. Pre-clinical studies show that VEGF influences growth and recovery of neurons. ;

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01246843
Study type	Observational
Source	Radboud University
Contact
Status	Completed
Phase	N/A
Start date	July 2009
Completion date	April 2011

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05957367` - A Study of DCC-3116 in Combination With Anticancer Therapies in Participants With Advanced Malignancies	Phase 1/Phase 2
Completed	`NCT01770405` - Clinical Registry of nCLE in Masses and Cystic Tumors of the Pancreas, Lymph Nodes, Submucosal Lesions of the GI Tract	N/A
Active, not recruiting	`NCT03556384` - Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)	Phase 2
Recruiting	`NCT05895942` - Exploring the Molecular Mechanism Based on KIT Mutation
Completed	`NCT01459757` - Non-Interventional Retrospective Correlation Of Tumor Mutational Status To Clinical Benefit Of GIST Patients Treated With Sunitinib	N/A
Completed	`NCT00979381` - Study of the Immunoresponse in Patients Treated With a Tyrosine Kinase Inhibitor	N/A
Completed	`NCT00399152` - Perifosine + Sunitinib Malate for Patients With Advanced Cancers	Phase 1
Recruiting	`NCT03715933` - Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas	Phase 1
Completed	`NCT04599660` - Study in Low Risk Gastrointestinal Stromal Tumor (GISTs)
Completed	`NCT05400018` - Clinical Evaluation of Genetron D842V PCR Kit in GIST Patients
Recruiting	`NCT03475953` - A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors	Phase 1/Phase 2
Not yet recruiting	`NCT04825470` - Liver Transplantation for Unresectable GIST Liver Metastases	N/A
Recruiting	`NCT00687778` - 11C-Acetate PET/CT Non-FDG-Avid Tumors	N/A
Completed	`NCT00979329` - Study on the Influence of Sunitinib and Sorafenib on Fatigue, QoL, Depression in Patients With Metastatic RCC or GIST	N/A
Active, not recruiting	`NCT04927260` - French Long Term Registry With Longitudinal Follow up of PDGFRA D842V-GIST Patients
Completed	`NCT03465722` - (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST	Phase 3
Completed	`NCT03880617` - Distress, Medication Adherence and Care Needs in Patients With CML and GIST Receiving Oral Targeted Therapy
Recruiting	`NCT03896958` - The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology)
Completed	`NCT01323400` - Efficacy of Pazopanib in Gastrointestinal Stromal Tumors (GIST)	Phase 2
Recruiting	`NCT05804331` - The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study