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Study of Sotorasib Combined With Chemotherapy for Second Line Treatment of Pancreas Cancer

Pancreatic Cancer Clinical Trial

Official title:
A Phase Ib/II Study of Sotorasib Combined With Chemotherapy for Second Line Treatment of KRAS p. G12C Mutated Advanced Pancreatic Cancer

Clinical Trial Summary

This is a multicenter, non-randomized, open-label, phase Ib/II study to evaluate the safety, tolerability and efficacy of sotorasib in combination with chemotherapy for patients with advanced KRAS p.G12C mutant pancreatic cancer with progression of disease after first line treatment. There will be a safety lead in to determine the safety and tolerability of the sotorasib in combination with standard chemotherapy. A Simon two-stage design will be employed to evaluate the efficacy of sotorasib in combination with standard of care second line chemotherapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05251038
Study type Interventional
Source Hoosier Cancer Research Network
Contact
Status Withdrawn
Phase Phase 1/Phase 2
Start date September 13, 2022
Completion date January 31, 2023
View Details
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