Metastatic Pancreatic Cancer Clinical Trial
Official title:
A Phase II, Single-arm Study to Evaluate The Safety and Efficacy of Apatinib Combined With Irinotecan and S-1 (ApaIRIS) in Treating Patients With Metastatic Pancreatic Cancer After Chemotherapy With Albumin-bound Paclitaxel Plus Gemcitabine Regimen
This is a single arm, open label Phase II clinical trial to evaluate the efficacy and safety of apatinib combined with irinotecan and S-1 (ApaIRIS) in treating Patients with metastatic pancreatic cancer after chemotherapy with albumin-bound paclitaxel plus gemcitabine regimen
While AG (albumin-bound paclitaxel + gemcitabine) is one of the preferred first-line
chemotherapy for metastatic pancreatic cancer, we have to investigate possible therapeutic
options after AG regimen. In this single arm, open-label clinical trial, metastatic
pancreatic cancer patients will be received apatinib, irinotecan and S-1. Treatment repeats
every 4 weeks until the disease recurrence or unacceptable toxicity, death or begin a novel
therapeutic.
The efficacy and safety data will be assessed through PFS, OS, ORR and adverse effects as
graded by CTC-AE 5.0.
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