Metastatic Pancreatic Cancer Clinical Trial
Official title:
Phase IB/II Trial of High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have Had No Prior Therapy for Their Metastatic Pancreatic Cancer
The purpose of this study is to see if a combination of paclitaxel protein bound (also known
as nab-paclitaxel), gemcitabine, and cisplatin when given with high dose Ascorbic Acid will
be safe and effective in individuals with untreated metastatic pancreatic cancer.
Vitamin C is a nutrient found in food and dietary supplements. It protects cells and also
plays a key role in making collagen (which provides strength and structure to skin, bones,
tissues and tendons). High-dose vitamin C may be given by intravenous (IV) infusion (through
a vein into the bloodstream) or orally (taken by mouth). When taken by intravenous infusion,
vitamin C can reach much higher levels in the blood than when the same amount is taken by
mouth. Some human studies of high-dose IV vitamin C in patients with cancer have shown
improved quality of life, as well as improvements in physical, mental, and emotional
functions, symptoms of fatigue, nausea and vomiting, pain, and appetite loss. Intravenous
high-dose ascorbic acid has caused very few side effects in clinical trials.
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