Metastatic Pancreatic Cancer Clinical Trial
Official title:
A Phase 1b/2 Study Evaluating IPI-926 in Combination With Gemcitabine in Patients With Metastatic Pancreatic Cancer
Study IPI-926-03 is a Phase 1b/2 clinical trial to evaluate IPI 926 in combination with
gemcitabine in patients with previously untreated metastatic pancreatic cancer. Phase 1b is
designed as a dose escalation study. Once the maximum tolerated dose of IPI-926 in
combination with gemcitabine is established in the Phase 1b portion of the study, the Phase
2 portion will commence.
Phase 2 is designed as a randomized, double-blind (investigator/patient), placebo-controlled
study. There is no cross-over option for patients in either arm of the Phase 2 (i.e., there
is no option for patients receiving placebo to cross-over to IPI-926).
IPI 926 is an inhibitor of the Hedgehog Pathway. IPI-926 in combination with gemcitabine may improve therapeutic outcomes in patients with pancreatic cancer. Infinity is conducting a Phase 1b/2 clinical trial to evaluate the safety and efficacy of IPI-926 in combination with gemcitabine in patients with previously untreated metastatic pancreatic cancer. ;
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