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A Study of LN-144 in People With Metastatic Melanoma to the Brain

Metastatic Melanoma Clinical Trial

Official title:
Pilot Trial of Lifileucel (LN-144) for Patients With Asymptomatic Melanoma Brain Metastases and Progression on Prior PD1 Therapy

Clinical Trial Summary

This is an open label study evaluating lifileucel (LN-144) in patients with melanoma brain metastases.

Clinical Trial Description

Lifileucel (LN-144) is an autologous Tumor Infiltrating Lymphocytes (TIL) cell therapy that utilizes a 22-day centralized GMP process. Lifileucel is infused as part of a treatment regimen that includes preparative NMA-LD, followed by one-time autologous TIL infusion, and a short course of high-dose IL-2. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05640193
Study type Interventional
Source Memorial Sloan Kettering Cancer Center
Contact
Status Active, not recruiting
Phase Phase 1
Start date November 25, 2022
Completion date November 2025
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