| Eligibility |
Inclusion Criteria:
1. Male/female participants who are at least 18 years of age on the day of signing
informed consent with histologically confirmed diagnosis of metastatic melanoma with
BRAF V600E/K mutation will be enrolled in this study.
2. Male participants:
A male participant must agree to use a contraception as detailed in Appendix 3 of this
protocol during the treatment period and for at least 125 days (5 terminal half-lives
for pembrolizumab) after the last dose of study treatment and refrain from donating
sperm during this period.
3. Female participants: A female participant is eligible to participate if she is not
pregnant, not breastfeeding, and at least one of the following conditions applies:
1. Not a woman of childbearing potential (WOCBP) as defined in Appendix 3 OR
2. A WOCBP who agrees to follow the contraceptive guidance in Appendix 3 during the
treatment period and for at least 120 days after the last dose of study
treatment.
4. Participants must have progressed on treatment with an anti-PD-1/L1 mAb administered
either as monotherapy or in combination with other checkpoint inhibitors or other
therapies. PD-1 treatment progression is defined by meeting all of the following
criteria:
1. Has received at least 2 doses of an approved anti-PD-1/L1 mAb. Note: participants
who have received prior anti-PD-1+ CTLA4 may be included in the study.
2. The last line prior to inclusion in the study must include an approved anti-PD-1
therapy.
3. Has demonstrated clinical PD after anti-PD-1/L1 The initial evidence of PD is to
be confirmed by a second assessment no less than 4 weeks from the date of the
first documented PD, in the absence of rapid clinical progression.
4. Progressive disease has been documented within 12 weeks from the last dose of
anti-PD-1/L1 mAb.
5. This determination is made by the investigator. Once PD is confirmed, the initial
date of PD documentation will be considered the date of disease progression.
5. The participant (or legally acceptable representative if applicable) provides written
informed consent for the trial.
6. Have measurable disease based on RECIST 1.1. Lesions situated in a previously
irradiated area are considered measurable if progression has been demonstrated in such
lesions.
7. Have not been previously treated with BRAF inhibitors and/or MEK inhibitors.
8. Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1.
Evaluation of ECOG is to be performed within 7 days prior to the date of treatment
initiation.
9. Have adequate organ function as defined below. Specimens must be collected within 10
days prior to the start of study treatment.
Adequate Organ Function Laboratory Values:
Absolute neutrophil count (ANC) =1500/µL Platelets =100 000/µL Hemoglobin =9.0 g/dL or =5.6
mmol/La Creatinine OR Measured or calculatedb creatinine clearance (GFR can also be used in
place of creatinine or CrCl) =1.5 × ULN OR =30 mL/min for participant with creatinine
levels >1.5 × institutional ULN Total bilirubin =1.5 ×ULN OR direct bilirubin =ULN for
participants with total bilirubin levels >1.5 × ULN AST (SGOT) and ALT (SGPT) =2.5 × ULN
(=5 × ULN for participants with liver metastases) Coagulation: International normalized
ratio (INR) OR prothrombin time (PT) Activated partial thromboplastin time (aPTT) =1.5 ×
ULN unless participant is receiving anticoagulant therapy as long as PT or aPTT is within
therapeutic range of intended use of anticoagulants.
Exclusion Criteria:
1. A WOCBP who has a positive urine pregnancy test within 72 hours prior to treatment
initiation. If the urine test is positive or cannot be confirmed as negative, a serum
pregnancy test will be required.
2. Has received prior systemic anti-cancer therapy including investigational agents
within 2 weeks prior to treatment initiation.
Note: Participants must have recovered from all AEs due to previous therapies to
=Grade 1 or baseline. Participants with =Grade 2 neuropathy may be eligible.
Note: If the participant had major surgery, they must have recovered adequately from
the toxicity and/or complications from the intervention prior to starting study
treatment.
3. Has received prior radiotherapy within 2 weeks of start of study intervention.
Participants must have recovered from all radiation-related toxicities, not require
corticosteroids, and not have had radiation pneumonitis. A 1-week washout is permitted
for palliative radiation (=2 weeks of radiotherapy) to non-CNS disease.
4. Has received a live vaccine within 30 days prior to the first dose of study drug.
Examples of live vaccines include, but are not limited to, the following: measles,
mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus
Calmette-Guérin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection
are generally killed virus vaccines and are allowed; however, intranasal influenza
vaccines (eg, FluMist®) are live attenuated vaccines and are not allowed.
5. Is currently participating in or has participated in a study of an investigational
agent or has used an investigational device within 4 weeks prior to the first dose of
study intervention.
Note: Participants who have entered the follow-up phase of an investigational study
may participate as long as it has been 4 weeks after the last dose of the previous
investigational agent.
6. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
(in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
immunosuppressive therapy within 7 days prior to the first dose of study drug.
7. Has a history of a second malignancy, unless potentially curative treatment has been
completed with no evidence of malignancy for 2 years.
Note: This time requirement does not apply to participants who underwent successful
definitive resection of basal cell carcinoma of the skin, squamous cell carcinoma of
the skin, superficial bladder cancer, in situ cervical cancer, or other in-situ
cancers
8. Has known active CNS metastases and/or carcinomatous meningitis. Participants with
previously treated brain metastases may participate provided they are radiologically
stable, i.e. without evidence of progression for at least 4 weeks by repeat imaging
(note that the repeat imaging should be performed during study screening), clinically
stable and without requirement of steroid treatment for at least 14 days prior to
first dose of study intervention.
9. Has severe hypersensitivity (=Grade 3) to pembrolizumab and/or any of its excipients.
10. Has active autoimmune disease that has required systemic treatment in the past 2 years
(i.e. with use of disease modifying agents, corticosteroids or immunosuppressive
drugs). Replacement therapy (eg., thyroxine, insulin, or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a
form of systemic treatment and is allowed.
11. Has a history of (non-infectious) pneumonitis that required steroids or has current
pneumonitis.
12. Has an active infection requiring systemic therapy.
13. Has a known history of Human Immunodeficiency Virus (HIV) infection.
14. Has a known history of Hepatitis B (defined as Hepatitis B surface antigen [HBsAg]
reactive) or known active Hepatitis C virus infection (defined as detected HCV RNA
[qualitative]).
15. Has a known history of active Bacillus Tuberculosis (TB).
16. Has a history or current evidence of any condition, therapy, or laboratory abnormality
that might confound the results of the study, interfere with the subject's
participation for the full duration of the study, or is not in the best interest of
the subject to participate, in the opinion of the treating investigator.
17. Has known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the trial.
18. Is pregnant or breastfeeding or expecting to conceive or father children within the
projected duration of the study, starting with the screening visit through 120 days
after the last dose of trial treatment.
19. Has had an allogenic tissue/solid organ transplant.
20. Baseline ejection fraction <50%, or below the institutional lower limit of normal
(LLN).
21. A history of retinal vein occlusion (RVO) or current risk factors for RVO including
uncontrolled glaucoma or a history of hyperviscosity or hypercoagulability syndromes.
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