Metronomic Therapy in Patients With Metastatic Melanoma

Status Terminated

Clinical Trial Summary

SUMMARY: Metronomic Therapy in Patients with Metastatic Melanoma: A Phase II Study of Low Dose Vinblastine, Cyclophosphamide, and Dacarbazine.

Patients with measurable metastatic melanoma are eligible. All patients will be treated as outlined below with combined vinblastine, cyclophosphamide, and dacarbazine. Patients will be treated continuously, until evidence of progression of disease, or for up to two cycles following disappearance of all disease. A cycle will be defined as three weeks of continuous therapy with a one week rest.

Clinical Trial Description

Low dose continuous chemotherapy, called metronomic chemotherapy, is designed to target vascular cells and inhibit tumor growth and metastasises. A recent study in a melanoma mouse model has identified low dose vinblastine, cyclophosphamide and dacarbazine as a treatment which improves the animal's survival and is superior to full dose dacarbazine alone. This clinical trial seeks to translate this laboratory model directly into metastatic melanoma patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01542255
Study type	Interventional
Source	Dartmouth-Hitchcock Medical Center
Contact
Status	Terminated
Phase	Phase 2
Start date	June 2010
Completion date	January 2013

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