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Clinical Trial Summary

This is a prospective, open-label, multicenter, single arm phase Ⅰb/Ⅱ clinical study aims to explore the efficacy and safety of fruquintinib combined with toripalimab and SOX regimen in the first-line treatment of unresectable advanced metastatic gastric or gastroesophageal junction adenocarcinoma.


Clinical Trial Description

At present, the first-line standard treatment of metastatic gastric cancer is still doublet or triplet chemotherapy of fluorouracil combined with platinum or paclitaxel. In recent years, immune checkpoint inhibitors (ICIs) have emerged in advanced gastric cancer with their unique mechanism of action. PD-1 monoclonal antibody has been explored in multiple combination schemes in the first-line treatment of advanced gastric cancer. This study aims to explore the efficacy and safety of an antiangiogenetic TKI, fruquintinib combined with an ICI, toripalimab and the standard doublet SOX regimen in the first-line treatment of unresectable advanced metastatic gastric or gastroesophageal junction adenocarcinoma. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05024812
Study type Interventional
Source The First Affiliated Hospital of Zhengzhou University
Contact Feng Wang, M.D.
Phone 860013938244776
Email fengw010@163.com
Status Recruiting
Phase Phase 1/Phase 2
Start date June 1, 2022
Completion date February 2025

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