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Clinical Trial Summary

This is a prospective, multi-center, randomized study evaluating the efficacy and safety of fruquintinib combined with chemotherapy vs bevacizumab combined with chemotherapy as second-line treatment in patients with metastatic colorectal cancer. Patients will receive fruquintinib+ FOLFIRI or bevacizumab+FOLFIRI as the second-line treatment. After receiving 4-6 months of second-line treatment, patients who achieve disease control will receive fruquintinib + capecitabine or bevacizumab+ capecitabine as maintenance treatment. All patients will be treated until progressive disease, death from any cause, unacceptable toxicity or informed consent withdrawal.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05555901
Study type Interventional
Source Fudan University
Contact Jianmin Xu, MD
Phone 86-21-6404-1990
Email xujmin@aliyun.com
Status Recruiting
Phase Phase 2
Start date June 18, 2023
Completion date September 2025

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