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Clinical Trial Summary

This phase II study aims to explore the efficacy and safety of fruquintinib combined with TAS-102 in the third-line treatment of patients with advanced metastatic colorectal cancer.


Clinical Trial Description

This is a prospective, single center, one-arm phase II study. A total of 54 advanced mCRC patients refractory to standard therapies will be enrolled and administered with fruquintinib (4mg/d, qd po, D1-21, Q4W) combined with TAS-102 (70mg/m2/d, bid po, D1-5, 8-12, Q4W) until intolerable toxicity, disease progression or death. Primary endpoint of this study is PFS and secondary endpoints are OS, ORR, DCR and safety. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05004831
Study type Interventional
Source Sun Yat-sen University
Contact Jianjun Peng, M.D.
Phone +8613602263939
Email pjianj@mail.sysu.edu.cn
Status Recruiting
Phase Phase 2
Start date March 11, 2022
Completion date September 2024

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