| Eligibility |
Inclusion Criteria:
1. Signed written informed consent before any trial-related procedure is undertaken that
is not part of the standard patient management
2. Male or female subjects aged = 18 years 3.Histologically proven diagnosis of
colorectal adenocarcinoma.
4. Diagnosis of metastatic disease 5. RAS (NRAS and KRAS exon 2,3 and 4) wild-type in
tissue at initial diagnosis. 6. Efficacy of a first line therapy containing an anti-EGFR
agent (panitumumab or cetuximab) with a major response achieved (complete or partial
response).
7. A second line therapy. 8. More than 4 months from last dose of anti-EGFR agent
administered in first line treatment before randomization. 9.Measurable disease according
to RECIST criteria v1.1 10 ECOG PS of 0 to 1 at trial entry 11. Estimated life expectancy
of more than 12 weeks 12. Adequate hematological function defined by white blood cell (WBC)
count = 2.5 × 109/L with absolute neutrophil count (ANC) = 1.5 × 109/L, lymphocyte count =
0.5 × 109/L, platelet count = 100 × 109/L, and hemoglobin = 9 g/dL (may have been
transfused) 13. Adequate hepatic function defined by a total bilirubin level
= 1.5 × the upper limit of normal (ULN) range and AST and alanine aminotransferase (ALT)
levels = 2.5 × ULN for all subjects or AST and ALT levels = 5 x ULN (for subjects with
documented metastatic disease to the liver).
14. Adequate renal function defined by an estimated creatinine clearance > 30 mL/min
according to the Cockcroft-Gault formula (or local institutional standard method) 15.
Effective contraception for both male and female subjects if the risk of conception exists
(Note: The effects of the trial drug on the developing human fetus are unknown; thus, women
of childbearing potential and men must agree to use effective contraception, defined as 2
barrier methods, or 1 barrier method with a spermicide, an intrauterine device, or use of
oral female contraceptive. Should a woman become pregnant or suspect she is pregnant while
she or her partner is participating in this trial, the treating physician should be
informed immediately.) Highly effective contraception for both male and female subjects
throughout the study and for at least 30 days after last avelumab treatment administration
if the risk of conception exists.
16. No prior immunotherapy
Exclusion Criteria:
Subjects are not eligible for this trial if they fulfill any of the following exclusion
criteria:
1. Any contraindication to cetuximab and/or avelumab.
2. Past or current history of malignancies other than colorectal carcinoma, except for
curatively treated basal and squamous cell carcinoma of the skin or in situ carcinoma
of the cervix.
3. Pregnancy 4.Breastfeeding
5. Participation in a clinical study or experimental drug treatment within 30 days.
6. Subjects receiving immunosuppressive agents (such as steroids) for any reason should be
tapered off these drugs before initiation of the trial treatment, with the exception of:
- subjects with adrenal insufficiency, who may continue corticosteroids at physiologic
replacement dose, equivalent to
= 10 mg prednisone daily
- intranasal, inhaled, topical steroids,
- local steroid injection (e.g., intra-articular injection)
- Systemic corticosteroids at physiologic doses = 10 mg/day of prednisone or equivalent
- Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication)
7. All subjects with brain metastases, except those meeting the following criteria:
- Brain metastases have been treated locally, and
- No ongoing neurological symptoms that are related to the brain localization of the
disease (sequelae that are a consequence of the treatment of the brain metastases are
acceptable) 8. Prior organ transplantation, including allogeneic stem-cell
transplantation 9. Significant acute or chronic infections including, among others:
- Known history of testing positive test for human immunodeficiency virus (HIV) or known
acquired immunodeficiency syndrome
- Hepatitis B virus (HBV) or hepatitis C virus (HCV) infection at screening (positive
HBV surface antigen or HCV RNA if anti-HCV antibody screening test positive) 10.
Active autoimmune disease that might deteriorate when receiving an immunostimulatory
agent:
- Subjects with diabetes type I, vitiligo, psoriasis, hypo- or hyperthyroid disease not
requiring immunosuppressive treatment are eligible
- Subjects requiring hormone replacement with corticosteroids are eligible if the
steroids are administered only for the purpose of hormonal replacement and at doses =
10 mg or equivalent prednisone per day.
- Administration of steroids through a route known to result in a minimal systemic
exposure (topical, intranasal, intro-ocular, or inhalation) are acceptable.
- Active infection requiring systemic therapy. 11. Previous or ongoing administration of
systemic steroids for the management of an acute allergic phenomenon is acceptable as
long as it is anticipated that the administration of steroids will be completed in 14
days, or that the daily dose after 14 days will be = 10 mg per day of equivalent
prednisone.
12. Known severe hypersensitivity to investigational product or any component in its
formulations, including known severe hypersensitivity reactions to monoclonal
antibodies (NCI CTCAE v4.03 Grade = 3), any history of anaphylaxis, or uncontrolled
asthma (that is, 3 or more feauters of partially controlled asthma).
13. History of hypersensitivity to Polysorbate 80 that led to unacceptable toxicity
requiring treatment cessation 14. Persisting toxicity related to prior therapy of
Grade > 1 NCI- CTCAE v 4.03.
15. Known alcohol or drug abuse. 16. Clinically significant (that is active)
cardioavscular disease: cerebral vascular accident/stroke (<6 months prior to
enrollment), myocardial infarction (<6 months prior to enrollment), unstable angina,
comgestive heart failure (New York Heart Association Classification Class=II), or
serious uncontrolled cardiac arrhytmia requiring medication 17. Other severe acute or
chronic medical conditions including immune colitis, inflammatory bowel disease,
immune pneumonitis, pulmonary fibrosis or psychiatric conditions including recent
(within the past year) or active suicidal ideation or behavior; or laboratory
abnormalities that may increase the risk associated with study participation or study
treatment administration or may interfere with the interpretation of study results
and, in the judgment of the investigator, would make the patient inappropriate for
entry into this study.
18. Any psychiatric condition that would prohibit the understanding or rendering of
informed consent.
19.Vaccination within 4 weeks of the first dose of avelumab and cetuximab and while on
treatment is prohibited except for administration of inactivated vaccine (i.e.
inactivated influenza vaccine) 20. Legal incapacity or limited legal capacity.
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