FOLFOXIRI Plus Cetuximab vs. FOLFOXIRI Plus Bevacizumab 1st-line in BRAF-mutated mCRC

Metastatic Colorectal Cancer Clinical Trial

— AIO-KRK-0116  

Official title:

Randomised Study to Investigate FOLFOXIRI Plus Cetuximab vs. FOLFOXIRI Plus Bevacizumab as First-line Treatment of BRAF-mutated Metastatic Colorectal Cancer

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04034459
• Other study ID #: FIRE-4.5
• Status: Active, not recruiting
• Phase: Phase 2
• Start date: November 25, 2016
• Est. completion date: December 31, 2023

Study information

• Verified date: November 2023
• Source: Ludwig-Maximilians - University of Munich
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Once randomisation has been completed, the study treatment should be started preferably immediately; at the latest within one week following randomisation.

The patients will be randomised in a ratio of 1:2 to the following two treatment arms.

Patients in both treatment arms will receive standard chemotherapy with FOLFOXIRI as background treatment, which can be de-escalated to FOLFIRI in case of toxicity.

Standard arm A:

The patient will be treated with FOLFOXIRI plus bevacizumab for up to 12 cycles (24 weeks) or until progression (if the latter occurs before completing the 12 cycles). Within the 12 cycles, the FOLFOXIRI plus bevacizumab regimen may be de-escalated, owing to toxicity, to FOLFIRI and bevacizumab at the treating physician's discretion.

After 12 cycles of the study treatment, a switch to a maintenance regimen with a fluoropyrimidine (5-FU infusion or capecitabine) plus bevacizumab, administered until progression occurs, is recommended. The recommended maintenance phase of the study is not part of the study treatment. However, maintenance therapy will be counted as first-line therapy.

Experimental arm B:

The patient will be treated with FOLFOXIRI plus weekly administration of cetuximab for up to 12 cycles (24 weeks) or until progression (if the latter occurs before completing the 12 cycles). Within the 12 cycles, the FOLFOXIRI plus cetuximab regimen may be de-escalated owing to toxicity, to FOLFIRI and cetuximab at the treating physician's discretion.

After 12 cycles, a switch to a maintenance regimen with 5-FU and cetuximab or with irinotecan and cetuximab, administered until progression occurs, is recommended. The recommended maintenance phase of the study is not part of the study treatment. However, maintenance therapy will be counted as first-line therapy.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 109
• Est. completion date: December 31, 2023
• Est. primary completion date: November 1, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Histologically confirmed UICC stage IV adenocarcinoma of the colon or rectum with metastases (metastatic colorectal cancer [mCRC]); metastases primarily non-resectable or surgery refused by the patient

• RAS wild-type tumour status (KRAS and NRAS exons 2, 3, 4) (proven in the primary tumour or metastasis)

• BRAF-mutant (V600E) tumour (proven in the primary tumour or metastasis)

• Age =18 years

• ECOG performance status 0-1

• Patients suitable for chemotherapy administration

• Patient's written declaration of consent obtained

• Estimated life expectancy > 3 months

• Presence of at least one measurable lesion according to the RECIST 1.1 - criteria (chest X-ray in two planes or chest CT and abdominal CT 4 weeks or less before randomisation)

• Primary tumour tissue available and patient consents to storage and molecular and genetic profiling of the tumour material. Molecular profiling of blood samples is optionally performed.

• Females of childbearing potential (FCBP) and men must agree to use effective contraceptive measures (Pearl index <1) for the duration of the study treatment and for at least 6 months after last administration of the study medication. A female subject will be considered to be of child-bearing potential unless she is = 50 years of age as well as has had a natural menopause for at least 2 years or has been surgically sterilised.

• Adequate bone marrow function:

• Leukocytes = 3.0 x 109/L with neutrophils = 1.5 x 109/L

• Thrombocytes = 100 x 109/L,

• Haemoglobin = 5.6 mmol/L (equivalent to 9 g/dL)

• Adequate hepatic function:

• Serum bilirubin = 1.5 x upper limit of normal (ULN),

• ALAT and ASAT = 2.5 x ULN (in case of hepatic metastasis, ALAT and ASAT = 5 x ULN)

• INR < 1.5 and aPTT < 1.5 x ULN (patients without anticoagulation). Therapeutic anticoagulation is allowed if INR and aPTT have remained stable within the therapeutic range for at least 2 weeks.

• Adequate renal function:

• Serum creatinine = 1.5 x ULN or creatinine clearance (calculated according to Cockcroft and Gault) = 50mL/min.

• Adequate cardiac function: ECG and echocardiogram with a LVEF of = 55%

• No previous chemotherapy for metastatic disease (prior radiotherapy of metastasis/metastases without application of chemotherapy permitted provided that no irradiated metastasis is selected as target lesion)

• Time interval since last administration of any previous neoadjuvant/adjuvant chemotherapy or radiochemotherapy =6 months

• Any relevant toxicities of previous treatments must have subsided to grade 0

Exclusion Criteria:

• Grade III or IV heart failure (NYHA classification)

• Myocardial infarction, unstable angina pectoris, balloon angioplasty (PTCA) with or without stenting within the past 12 months before randomisation

• Pregnancy (absence of pregnancy has to be ascertained by a beta hCG test) or breast feeding

• Medical or psychological impairments associated with restricted ability to give consent or not allowing conduct of the study

• Additional cancer treatment (chemotherapy, radiation, immune therapy or hormone treatment) during the study treatment. Treatments that are conducted as part of an anthroposophical or homeopathic treatment approach, e.g. mistletoe therapy, do not represent an exclusion criterion.

• Previous chemotherapy for the colorectal cancer with exception of chemotherapy or radiochemotherapy given as neoadjuvant or adjuvant treatment with curative intent, completed =6 months before entering the study.

• Participation in a clinical study or experimental drug treatment within 30 days prior to study inclusion or within a period of 5 half-lives of the substances administered in a clinical study or during an experimental drug treatment prior to inclusion in the study, depending on which period is longest, or simultaneous participation in another clinical study while taking part in the study

• Known hypersensitivity or allergic reaction to any of the following substances:

5-fluorouracil, folinic acid, cetuximab, irinotecan, bevacizumab, oxaliplatin and chemically related substances and/or hypersensitivity to any of the excipients of any of the aforementioned substances

• Known hypersensitivity to CHO (Chinese hamster ovary cells) - cell products or other recombinant human or humanised antibodies

• Patients with confirmed cerebral metastases. In case of clinical suspicion of brain metastases, a cranial CT or MRI must be performed to rule out brain metastases before study inclusion.

• History of acute or subacute intestinal occlusion or chronic inflammatory bowel disease or chronic diarrhoea.

• Symptomatic peritoneal carcinosis

• Severe, non-healing wounds, ulcers or bone fractures

• Patients with active infection (including confirmed HIV and/or HBV/HCV infection). In case of clinical suspicion of the presence of HIV or HBV/HCV infection, the latter should be ruled out before study inclusion.

• Requirement for immunisation with live vaccine during the study treatment.

• Uncontrolled hypertension

• Marked proteinuria (nephrotic syndrome)

• Arterial thromboembolism or severe haemorrhage within 6 months prior to randomisation (with the exception of tumour bleeding before tumour resection surgery)

• Haemorrhagic diathesis or tendency towards thrombosis

• Known DPD deficiency (specific screening not required)

• Known glucuronidation deficiency (Gilbert's syndrome) (specific screening not required)

• History of a second malignancy during the 5 years before inclusion in the study or during participation in the study, with the exception of a basal cell or squamous cell carcinoma of the skin or cervical carcinoma in situ, if these were treated curatively.

• Known history of alcohol or drug abuse

• A significant concomitant disease, in particular chronic hepatic or renal disease, chronic inflammatory or autoimmune diseases, ruling out the patient's participation in the study according to investigator's judgement.

• Absent or restricted legal capacity

Related Conditions & MeSH terms

• Colorectal Neoplasms
• Metastatic Colorectal Cancer

Intervention

Drug:
• Bevacizumab
Bevacizumab 5 mg/kg BW iv over 30 to 90* min day 1
• Irinotecan
Irinotecan 150 mg/m² iv, 30 - 90 min. day 1
• Folinic acid
Folinic acid (racemic) 400 mg/m² iv, 120 min. day 1
• Oxaliplatin
Oxaliplatin 85mg/m² day 1
• 5-FU
5-FU 3000 mg/m² iv over 48 h days 1-2
• Cetuximab
Cetuximab initially 400 mg/m² with infusion rate of =5 mg/min., subsequently 250 mg/m² iv with infusion rate of =10 mg/min. days 1+8

Locations

Country	Name	City	State
Germany	Klinikum der Universitaet Muenchen	Munich

Sponsors (1)

Lead Sponsor	Collaborator
Ludwig-Maximilians - University of Munich

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Overall Response Rate (ORR)	(overall response rate) measured in percentage of all treated patients according to RECIST 1.1 criteria	up to 48 months
Secondary	Progression Free Survival (PFS)	Investigation of progression-free survival (PFS) from randomisation	up to 60 months
Secondary	Overall Survival (OS)	Investigation of overall survival (OS) from randomisation	up to 60 months
Secondary	Investigation of Early Tumour Shrinkage (ETS) as early-on-Treatment predictor for treatment	Investigation of early tumour shrinkage (ETS)	up to 48 months
Secondary	Investigation of Depth of Response (DpR) to define nadir for tumour response.	Investigation of depth of response (DpR)	up to 48 months
Secondary	Investigation of Molecular Biomarkers for Prediction of an Anti-EGFR Treatment	Investigation of molecular biomarkers for prediction of sensitivity and secondary resistance of an anti-EGFR treatment with cetuximab (including tumour biopsies and liquid biopsies from blood samples)	up to 48 months
Secondary	Prospective Analysis of Tumour Marker Level Evolution (CEA and CA 19-9)	Investigation of prospective analysis of tumour marker level evolution (CEA and CA 19-9)	up to 48 months
Secondary	Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]	Recording of the safety and tolerability (NCI-CTCAE version 4.03 criteria) of the treatment	up to 48 months