Metastatic Colorectal Cancer Clinical Trial
Official title:
Phase II Study of Toripalimab (JS001) Plus Stereotactic Body Radiotherapy in Colorectal Cancer Patients With Oligometastasis
Metastatic colorectal cancer is one of the common malignant tumors and the overall prognosis
is poor. The introduction of immune-checkpoint inhibition (ICI) has led to a paradigm shift
in the treatment of patients with metastatic cancer. Stereotactic body radiation therapy
(SBRT) delivers a large dose of radiation to the tumor target with high precision while
sparing irradiation of the surrounding normal tissues. It is suggested that SBRT could be the
most appropriate radiotherapy modality to be combined with immunotherapy since it induces the
expression of a series of cytokines and new tumour-associated antigens (TAAs) and is more
likely to cause intense immune response and exert an abscopal effect than conventional
radiotherapy.
Thus, this study is to explore the use of SBRT in combination with ICI in colorectal cancer
patients with oligometastasis, in order to get better local and systemic tumor control and
improve progress-free survival (PFS).
The investigators plan to recruit patients with mCRC, who have received first-line systemic therapy for more than 3 months and achieved PR/SD. Than all the patients will receive SBRT followed by ICI therapy. ;
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