Metastatic Colorectal Cancer Clinical Trial
Official title:
A Pilot Study Investigating the Effect of Atezolizumab Monotherapy and Atezolizumab Plus Cobimetinib on the Tumoral Immunoprofile in Liver Metastases From Colorectal Cancer
This study is for patients with metastatic colorectal cancer who are candidates for resection
of metastases. This study will be conducted sequentially with 2 cohorts: 1.) Monotherapy
Cohort and 2.) Combination Cohort
Pre-metastatectomy
- Monotherapy Cohort: The first 10 subjects will receive Atezolizumab 840 mg IV on Day 1
and Day 15 of each 28-day cycle.
- Combination Cohort: The next 15 subjects will receive Atezolizumab 840 mg IV on Day 1
and Day 15 and Cobimetinib 60 mg PO on Days 1-21 of each 28-day cycle. Note: Cobimetinib
must be held for the 7 days prior to metastatectomy.
All subjects will be treated for 2 cycles (8 weeks) prior to metastatectomy
Metastatectomy
Subjects will undergo liver metastatectomy within 42 days of completion of Cycle 2 of
pre-metastatectomy treatment. No study treatment is administered while the patient is healing
after surgery.
Post-metastatectomy
Once the patient has healed from the surgery, adjuvant treatment may be administered at the
discretion of the treating physician. Restaging following standards of care for this setting.
n/a
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