Metastatic Colorectal Cancer Clinical Trial
The optimum regimen of maintenance treatment after first-line chemotherapy in patients with
metastatic colorectal cancer （mCRC） is unknown. This study was designed to determine the
efficacy and safety of maintenance treatment with capecitabine metronomic chemotherapy plus
Chinese Traditional Medicine.
In this Prospective, open-label, randomised controlled trial, the investigators will recruit
159 mCRC patients who have finished 18 to 24 weeks first-line chemotherapy and disease
evaluation is SD, PR or CR. The patients will then accept Chinese traditional diagnosis and
be randomised into two group, capecitabine metronomic chemotherapy only as control group and
the metronomic chemotherapy plus Chinese Traditional Medicine as experimental group. This
treatment regimen will be continued until progression, death, or an unacceptable adverse
event.
The primary endpoint is progression-free survival (PFS). Secondary endpoints are overall
survival (OS), quality of life (QOL) and toxic effects.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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